卡泊三醇倍他米松二丙酸酯凝胶联合治疗中重度头皮脂溢性皮炎的作用
The Role of Combination Calcipotriol plus Betamethasone Dipropionate Gel in the Treatment of Moderate-to-Severe Scalp Seborrhoeic Dermatitis.
作者信息
Yap Felix B
机构信息
Department of Medicine, Faculty of Medicine & Health Sciences, Universiti Tunku Abdul Rahman, Kajang, Selangor, Malaysia.
出版信息
Sultan Qaboos Univ Med J. 2018 Nov;18(4):e520-e523. doi: 10.18295/squmj.2018.18.04.015. Epub 2019 Mar 28.
OBJECTIVES
This study aimed to investigate the off-label use of a combination calcipotriol plus betamethasone dipropionate (CBD) gel in the treatment of moderate-to-severe scalp seborrhoeic dermatitis (SSD).
METHODS
This retrospective study involved 32 patients with SSD who were prescribed CBD gel at the Subang Jaya Medical Centre, Selangor, Malaysia, between January 2016 and December 2017. The Physician Global Assessment Scale was used to assess disease severity. Itching/discomfort was evaluated using a visual analogue scale.
RESULTS
The mean age was 35.8 ± 6.9 years. Severe disease was seen in 53.1%. Complete clearance was recorded in 15.6%, 40.6% and 59.4% of patients at weeks two, six and 10, respectively. By week 10, 87.5% had achieved marked improvement. Both mean itching and discomfort scores significantly improved at weeks two, six and 10 ( <0.001). Better outcomes were significantly associated with disease duration and itching intensity and discomfort at presentation ( <0.050).
CONCLUSION
CBD gel should be considered as an option for SSD cases not adequately controlled by prior conventional treatment.
目的
本研究旨在调查卡泊三醇倍他米松二丙酸酯（CBD）凝胶联合使用在治疗中度至重度头皮脂溢性皮炎（SSD）中的超说明书用药情况。
方法
这项回顾性研究纳入了2016年1月至2017年12月期间在马来西亚雪兰莪梳邦再也医疗中心被处方使用CBD凝胶的32例SSD患者。采用医生整体评估量表评估疾病严重程度。使用视觉模拟量表评估瘙痒/不适情况。
结果
平均年龄为35.8±6.9岁。53.1%的患者病情严重。分别在第2周、第6周和第10周，15.6%、40.6%和59.4%的患者实现了完全清除。到第10周时，87.5%的患者有显著改善。在第2周、第6周和第10周，平均瘙痒和不适评分均显著改善（<0.001）。更好的治疗效果与疾病持续时间、就诊时的瘙痒强度和不适显著相关（<0.050）。
结论
对于先前常规治疗控制不佳的SSD病例，CBD凝胶应被视为一种选择。
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