Verra Wiebe C, Boom Lennard G H van den, Jacobs Wilco C H, Schoones Jan W, Wymenga Ate B, Nelissen Rob G H H
Department of Orthopaedic Surgery , Leiden University Medical Center , Leiden.
Acta Orthop. 2015 Apr;86(2):195-201. doi: 10.3109/17453674.2014.973329. Epub 2014 Oct 17.
To retain or to sacrifice the posterior cruciate ligament (PCL) in total knee arthroplasty (TKA) remains a matter of discussion. In this systematic review, we wanted to find differences in functional and clinical outcome between the 2 methods.
We conducted a systematic review and meta-analysis including all randomized controlled trials (RCTs) and quasi-RCTs that have compared PCL retention with PCL sacrifice in TKA with a minimum of 1-year follow-up. Primary outcome was range of motion. Secondary outcomes were knee pain and clinical scoring systems that were preferably validated. Quality of evidence was graded using the GRADE approach. All outcomes available for data pooling were used for meta-analysis.
20 studies involving 1,877 patients and 2,347 knees were included. In meta-analysis, the postoperative flexion angle had a mean difference of 2 degrees (95% CI: 0.23-4.0; p = 0.03) and the KSS functional score was 2.4 points higher in favor of PCL sacrifice (95% CI: 0.41-4.3; p = 0.02). There were no statistically significant differences regarding other measured clinical outcomes such as WOMAC, KSS pain, clinical and overall score, HSS score, SF-12, radiolucencies, femoro-tibial angle, and tibial slope. The quality of the studies varied considerably. Risk of bias in most studies was unclear; 5 were judged to have a low risk of bias and 5 to have a high risk of bias.
We found no clinically relevant differences between retention and sacrifice of the PCL in TKA, in terms of functional and clinical outcomes. The quality of the studies ranged from moderate to low. Based on the current evidence, no recommendation can be made as to whether to retain or to sacrifice the PCL.
在全膝关节置换术(TKA)中,保留或牺牲后交叉韧带(PCL)仍是一个有争议的问题。在本系统评价中,我们旨在找出这两种方法在功能和临床结局方面的差异。
我们进行了一项系统评价和荟萃分析,纳入了所有比较TKA中PCL保留与PCL牺牲且随访至少1年的随机对照试验(RCT)和半随机对照试验(quasi-RCT)。主要结局是活动范围。次要结局是膝关节疼痛和经过较好验证的临床评分系统。采用GRADE方法对证据质量进行分级。所有可用于数据合并的结局均用于荟萃分析。
纳入了20项研究,涉及1877例患者和2347个膝关节。在荟萃分析中,术后屈曲角度的平均差异为2°(95%CI:0.23 - 4.0;p = 0.03),KSS功能评分有利于PCL牺牲,高2.4分(95%CI:0.41 - 4.3;p = 0.02)。在其他测量的临床结局方面,如WOMAC、KSS疼痛、临床和总分、HSS评分、SF - 12、透亮区、股骨 - 胫骨角和胫骨坡度,没有统计学上的显著差异。研究质量差异很大。大多数研究的偏倚风险不明确;5项被判定为低偏倚风险,5项为高偏倚风险。
我们发现在TKA中,PCL保留和牺牲在功能和临床结局方面没有临床相关差异。研究质量从中度到低度不等。基于目前的证据,对于是否保留或牺牲PCL无法给出推荐。