Burne R, Taylor R
Hull York Medical School, Heslington, York, UK.
Ophthalmology Department, York Hospital, York, UK.
Eye (Lond). 2014 Nov;28(11):1281-4; quiz 1285. doi: 10.1038/eye.2014.237. Epub 2014 Oct 17.
To develop a tool for assessing amblyopic risk and monitoring the treatment effect of propranolol in periocular haemangioma management.
We present a study of nine children with periocular haemangioma who underwent propranolol treatment at York Hospital between 2009 and 2013.A proposed measure of amblyogenic risk based on the induced anisometropia resulting from a periocular haemangioma was calculated in the form of a single quantitative value, measured in dioptres. This calculation used published work and developed it to produce a new function, termed the delta defocus equivalent (DFE-∂).Refraction measurements were retrospectively collected from patients' notes in order to measure the trend of DFE-∂ over the treatment period with propranolol.
The average DFE-∂ at commencement of propranolol was 1.54 (±0.62) D. The average at the end of treatment was 0.39 (±0.38) D.
This work presents a possible tool for assessing amblyopic risk in cases of periocular infantile haemangioma. The DFE-∂ gives a measure in dioptres, which may represent the true amblyopic risk, and so be useful in supporting treatment decisions in paediatric ophthalmology.
开发一种工具，用于评估眼周血管瘤患者的弱视风险，并监测普萘洛尔在眼周血管瘤治疗中的效果。
我们对2009年至2013年间在约克医院接受普萘洛尔治疗的9例眼周血管瘤患儿进行了一项研究。基于眼周血管瘤引起的诱导性屈光参差，计算出一种拟议的致弱视风险测量值，以单一量化值的形式表示，单位为屈光度。该计算采用已发表的研究成果并加以拓展，得出一个新的函数，称为等效散焦增量（DFE-∂）。为了测量DFE-∂在普萘洛尔治疗期间的变化趋势，我们回顾性收集了患者病历中的验光测量数据。
普萘洛尔治疗开始时，DFE-∂的平均值为1.54（±0.62）D。治疗结束时的平均值为0.39（±0.38）D。
本研究提出了一种评估眼周婴幼儿血管瘤弱视风险的可能工具。DFE-∂以屈光度为单位给出一个测量值，这可能代表真正的弱视风险，因此有助于支持小儿眼科的治疗决策。
