Corominas-Faja Bruna, Santangelo Elvira, Cuyàs Elisabet, Micol Vicente, Joven Jorge, Ariza Xavier, Segura-Carretero Antonio, García Jordi, Menendez Javier A
Metabolism and Cancer Group, Translational Research Laboratory, Catalan Institute of Oncology (ICO), Girona, Spain. Girona Biomedical Research Institute (IDIBGI), Girona, Spain.
Departament de Química Orgànica, Fac. de Química, Institut de Biomedicina de la UB (IBUB), Universitat de Barcelona, Barcelona, Spain.
Aging (Albany NY). 2014 Sep;6(9):731-41. doi: 10.18632/aging.100691.
Aging is associated with common conditions, including cancer, diabetes, cardiovascular disease, and Alzheimer's disease. The type of multi-targeted pharmacological approach necessary to address a complex multifaceted disease such as aging might take advantage of pleiotropic natural polyphenols affecting a wide variety of biological processes. We have recently postulated that the secoiridoids oleuropein aglycone (OA) and decarboxymethyl oleuropein aglycone (DOA), two complex polyphenols present in health-promoting extra virgin olive oil (EVOO), might constitute a new family of plant-produced gerosuppressant agents. This paper describes an analysis of the biological activity spectra (BAS) of OA and DOA using PASS (Prediction of Activity Spectra for Substances) software. PASS can predict thousands of biological activities, as the BAS of a compound is an intrinsic property that is largely dependent on the compound's structure and reflects pharmacological effects, physiological and biochemical mechanisms of action, and specific toxicities. Using Pharmaexpert, a tool that analyzes the PASS-predicted BAS of substances based on thousands of "mechanism-effect" and "effect-mechanism" relationships, we illuminate hypothesis-generating pharmacological effects, mechanisms of action, and targets that might underlie the anti-aging/anti-cancer activities of the gerosuppressant EVOO oleuropeins.
衰老与多种常见疾病相关，包括癌症、糖尿病、心血管疾病和阿尔茨海默病。应对诸如衰老这种复杂多面疾病所需的多靶点药理学方法，可能会利用影响多种生物过程的多效性天然多酚。我们最近推测，橄榄苦苷苷元（OA）和脱羧甲基橄榄苦苷苷元（DOA）这两种存在于具有健康促进作用的特级初榨橄榄油（EVOO）中的复杂多酚，可能构成一类新的植物源性衰老抑制因子。本文描述了使用PASS（物质活性谱预测）软件对OA和DOA的生物活性谱（BAS）进行的分析。PASS可以预测数千种生物活性，因为化合物的BAS是一种内在属性，很大程度上取决于化合物的结构，并反映药理作用、生理和生化作用机制以及特定毒性。使用Pharmaexpert这个基于数千种“机制-效应”和“效应-机制”关系来分析PASS预测的物质BAS的工具，我们阐明了可能构成衰老抑制性EVOO橄榄苦苷抗衰老/抗癌活性基础的、能产生假设的药理作用、作用机制和靶点。
