偏头痛与心脑血管关联的实际影响：患者未满足的需求。
Practical implications of the migraine cardio- and cerebrovascular association: unmet needs of patients.
作者信息
Diener Hans-Christoph, Kurth Tobias, Holle Dagny
机构信息
Department of Neurology and Headache Center, University Hospital Essen, Germany
Inserm Research Center for Epidemiology and Biostatistics (U897)-Team Neuroepidemiology, Bordeaux, France University of Bordeaux, College of Health Sciences, Bordeaux, France.
出版信息
Cephalalgia. 2015 Feb;35(2):140-5. doi: 10.1177/0333102414554662. Epub 2014 Oct 16.
BACKGROUND
Numerous studies have described a relationship between migraine and stroke, and there is emerging evidence that migraine is also associated with cardiovascular disease. The combination of migraine and both cerebrovascular and cardiovascular disease has implications for therapy.
METHODS
We conducted a review of the modifications in medical therapy in patients with comorbid migraine and cardio- and cerebrovascular disorders based on publications from the last 15 years.
RESULTS
Some drugs are contraindicated to treat migraine attacks (ergots, triptans) or for migraine prevention in patients after transient ischemic attack (TIA)/ischemic stroke. Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated in patients with cerebral bleeding. Some drugs for the treatment of acute migraine attacks are contraindicated in patients with symptomatic coronary heart disease.
CONCLUSIONS
Given the large number of patients with comorbid migraine and cardiovascular as well as cerebrovascular disease, there is an unmet need to treat these patients.
背景
众多研究描述了偏头痛与中风之间的关系，并且有新证据表明偏头痛还与心血管疾病有关。偏头痛与脑血管和心血管疾病并存对治疗有影响。
方法
我们基于过去15年的出版物，对偏头痛与心脑血管疾病并存患者的药物治疗调整进行了综述。
结果
某些药物在短暂性脑缺血发作（TIA）/缺血性中风后患者中，禁止用于治疗偏头痛发作（麦角胺、曲坦类药物）或预防偏头痛。脑出血患者禁用阿司匹林和非甾体抗炎药（NSAIDs）。一些用于治疗急性偏头痛发作的药物在有症状性冠心病患者中禁用。
结论
鉴于有大量偏头痛与心血管及脑血管疾病并存的患者，治疗这些患者的需求尚未得到满足。
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