Jeong Nam-Ji, Park Seung-Bae, Im Myung, Seo Young-Joon, Lee Jeung-Hoon, Lee Young
Department of Dermatology, Chungnam National University School of Medicine, Daejeon, Korea.
Ann Dermatol. 2014 Oct;26(5):621-3. doi: 10.5021/ad.2014.26.5.621. Epub 2014 Sep 26.
Anetoderma is a rare cutaneous disorder characterized by a loss of normal elastic tissue that presents clinically as atrophic patches located mainly on the upper trunk. Recent studies suggest immunological mechanisms may play a role in this process. Furthermore, a secondary form of macular atrophy occurs in the course of infectious diseases (e.g. syphilis and tuberculosis) and autoimmune disease (e.g. systemic lupus erythematosus [SLE]). Here, we report the case of a 20-year-old woman previously diagnosed with SLE, who presented with numerous well-circumscribed atrophic macules on the face and upper trunk. Histopathological examination showed decreased elastic tissues in the reticular dermis and mononuclear cells adhering to elastic fibers, consistent with anetoderma. Thus, the eruptive anetoderma localized widely on the face and upper trunk may have been caused by an autoimmune response of SLE.
皮肤松弛症是一种罕见的皮肤疾病，其特征是正常弹性组织丧失，临床上表现为主要位于上躯干的萎缩性斑块。最近的研究表明，免疫机制可能在这个过程中起作用。此外，继发性黄斑萎缩发生在传染病（如梅毒和结核病）和自身免疫性疾病（如系统性红斑狼疮[SLE]）的病程中。在此，我们报告一例20岁曾被诊断为SLE的女性患者，其面部和上躯干出现大量边界清晰的萎缩性斑疹。组织病理学检查显示网状真皮中弹性组织减少，单核细胞粘附于弹性纤维，符合皮肤松弛症表现。因此，广泛分布于面部和上躯干的暴发性皮肤松弛症可能是由SLE的自身免疫反应引起的。
