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萎缩性皮肤异色症的临床免疫组织病理学研究：隆起型比凹陷型更处于晚期阶段吗？

A Clinicoimmunohistopathologic Study of Anetoderma: Is Protruding Type More Advanced in Stage Than Indented Type?

机构信息

Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

出版信息

J Immunol Res. 2016;2016:4325463. doi: 10.1155/2016/4325463. Epub 2016 Dec 28.

DOI:10.1155/2016/4325463
PMID:28116317
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5225372/
Abstract

. The clinical and histopathologic classification of anetoderma are not well characterized. . We aimed to investigate the clinical and histopathologic characteristics of anetoderma and to correlate clinical phenotypes with immunohistopathologic findings. . We retrospectively reviewed the medical records of 30 patients with anetoderma and performed immunohistochemistry for elastin, fibrillin-1, metalloproteinase- (MMP-) 2, MMP-7, MMP-9, and MMP-12, and tissue inhibitor of metalloproteinase- (TIMP-) 1 and TIMP-2. . Protruding type ( = 17) had a longer disease duration and more severe loss of elastin, without changes in fibrillin, than indented type ( = 13). MMP-2 and MMP-9 showed significantly higher expressions in the dermis compared with controls ( < 0.05). MMP-7 and MMP-12 showed little expressions in both anetoderma and control tissue. TIMP-1 was highly expressed in anetoderma lesions and controls. TIMP-2 expression was variable. . Our findings suggest that protruding type anetoderma may represent a more advanced stage and that MMP-2 and MMP-9 could be responsible for elastic fiber degradation in anetoderma.

摘要

. 播散性弹性纤维溶解症的临床和组织病理学分类尚未明确。. 本研究旨在探讨播散性弹性纤维溶解症的临床和组织病理学特征，并将临床表型与免疫组织病理学结果相关联。. 我们回顾性分析了 30 例播散性弹性纤维溶解症患者的病历资料，并进行了弹力蛋白、原纤维蛋白-1、基质金属蛋白酶- (MMP-) 2、MMP-7、MMP-9、MMP-12、金属蛋白酶组织抑制剂- (TIMP-) 1 和 TIMP-2 的免疫组织化学染色。. 隆起型（=17 例）的疾病持续时间更长，弹力蛋白丢失更严重，而原纤维蛋白无变化，凹陷型（=13 例）则相反。MMP-2 和 MMP-9 在真皮中的表达明显高于对照组（<0.05）。MMP-7 和 MMP-12 在播散性弹性纤维溶解症组织和对照组中表达均较少。TIMP-1 在播散性弹性纤维溶解症病变和对照组中均呈高表达。TIMP-2 的表达则存在差异。. 我们的研究结果表明，隆起型播散性弹性纤维溶解症可能代表更晚期的阶段，MMP-2 和 MMP-9 可能负责播散性弹性纤维溶解症中弹性纤维的降解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135c/5225372/cc4d0ccf1b80/JIR2016-4325463.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135c/5225372/ee86e9b7667c/JIR2016-4325463.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135c/5225372/c0c3b8151deb/JIR2016-4325463.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135c/5225372/d782be996c0b/JIR2016-4325463.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135c/5225372/dd76bcb89e2f/JIR2016-4325463.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135c/5225372/cc4d0ccf1b80/JIR2016-4325463.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135c/5225372/ee86e9b7667c/JIR2016-4325463.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135c/5225372/c0c3b8151deb/JIR2016-4325463.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135c/5225372/d782be996c0b/JIR2016-4325463.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135c/5225372/dd76bcb89e2f/JIR2016-4325463.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135c/5225372/cc4d0ccf1b80/JIR2016-4325463.005.jpg

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