Clozel J P, Kuhn H, Hefti F
Pharmaceutical Research Department, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Am J Med. 1989 Dec 26;87(6B):92S-95S. doi: 10.1016/0002-9343(89)90102-2.
The goal of the present study was to describe the relative extent of vascular hypertrophy in four different types of arteries (coronary, renal, carotid, and mesenteric) of spontaneously hypertensive rats (SHR) and to evaluate the effects of long-term treatment with cilazapril, a new long-acting angiotensin-converting enzyme inhibitor on this vascular hypertrophy. For this purpose, a group of spontaneously hypertensive rats treated for four months with cilazapril (10 mg/kg orally) was compared with a group of spontaneously hypertensive rats treated with placebo. Another group of Wistar Kyoto (WKY) rats treated with placebo was used as a reference. At the end of the treatment period, the rats were perfused-fixed and morphometry of the carotid, renal, mesenteric and coronary arteries was performed. Vascular hypertrophy (increase of the thickness of the medial layer) was present in the four different types of arteries in a similar extent. Cilazapril normalized completely the arterial wall thickness:diameter ratio in the four different types of arteries. Further studies are required to determine whether this effect of cilazapril was due to the decrease of arterial blood pressure or to an effect of cilazapril on growth factors such as angiotensin II.
本研究的目的是描述自发性高血压大鼠（SHR）四种不同类型动脉（冠状动脉、肾动脉、颈动脉和肠系膜动脉）中血管肥大的相对程度，并评估新型长效血管紧张素转换酶抑制剂西拉普利长期治疗对这种血管肥大的影响。为此，将一组用西拉普利（10mg/kg口服）治疗四个月的自发性高血压大鼠与一组用安慰剂治疗的自发性高血压大鼠进行比较。另一组用安慰剂治疗的Wistar Kyoto（WKY）大鼠用作对照。在治疗期结束时，对大鼠进行灌注固定，并对颈动脉、肾动脉、肠系膜动脉和冠状动脉进行形态测量。四种不同类型动脉中均存在类似程度的血管肥大（中层厚度增加）。西拉普利使四种不同类型动脉的动脉壁厚度与直径之比完全恢复正常。需要进一步研究以确定西拉普利的这种作用是由于动脉血压降低还是西拉普利对诸如血管紧张素II等生长因子的作用。
