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聚合物-脂质杂化纳米粒的一步法组装用于米托蒽醌递送。

Single-step assembly of polymer-lipid hybrid nanoparticles for mitomycin C delivery.

机构信息

The Affiliated Southeast Hospital of Xiamen University, Xiamen University, Zhangzhou 363000, China.

Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, China ; Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.

出版信息

Nanoscale Res Lett. 2014 Oct 8;9(1):560. doi: 10.1186/1556-276X-9-560. eCollection 2014.

DOI:10.1186/1556-276X-9-560
PMID:25324707
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4198073/
Abstract

Mitomycin C is one of the most effective chemotherapeutic agents for a wide spectrum of cancers, but its clinical use is still hindered by the mitomycin C (MMC) delivery systems. In this study, the MMC-loaded polymer-lipid hybrid nanoparticles (NPs) were prepared by a single-step assembly (ACS Nano 2012, 6:4955 to 4965) of MMC-soybean phosphatidyhlcholine (SPC) complex (Mol. Pharmaceutics 2013, 10:90 to 101) and biodegradable polylactic acid (PLA) polymers for intravenous MMC delivery. The advantage of the MMC-SPC complex on the polymer-lipid hybrid NPs was that MMC-SPC was used as a structural element to offer the integrity of the hybrid NPs, served as a drug preparation to increase the effectiveness and safety and control the release of MMC, and acted as an emulsifier to facilitate and stabilize the formation. Compared to the PLA NPs/MMC, the PLA NPs/MMC-SPC showed a significant accumulation of MMC in the nuclei as the action site of MMC. The PLA NPs/MMC-SPC also exhibited a significantly higher anticancer effect compared to the PLA NPs/MMC or free MMC injection in vitro and in vivo. These results suggested that the MMC-loaded polymer-lipid hybrid NPs might be useful and efficient drug delivery systems for widening the therapeutic window of MMC and bringing the clinical use of MMC one step closer to reality.

摘要

丝裂霉素 C 是一种广谱抗癌的最有效化疗药物之一，但由于其递送系统的限制，其临床应用仍受到阻碍。在这项研究中，通过将丝裂霉素 C-大豆卵磷脂（MMC-SPC）复合物（Mol. Pharmaceutics 2013, 10:90 to 101）和可生物降解的聚乳酸（PLA）聚合物一步组装（ACS Nano 2012, 6:4955 to 4965）制备了载丝裂霉素 C 的聚合物-脂质混合纳米颗粒（NPs），用于静脉内递送丝裂霉素 C。MMC-SPC 复合物在聚合物-脂质混合 NPs 中的优势在于，MMC-SPC 既可以作为结构元件提供混合 NPs 的完整性，又可以作为药物制剂提高疗效和安全性并控制 MMC 的释放，还可以作为乳化剂促进和稳定其形成。与 PLA NPs/MMC 相比，PLA NPs/MMC-SPC 表现出 MMC 向细胞核（MMC 的作用部位）的显著聚集。PLA NPs/MMC-SPC 与 PLA NPs/MMC 或游离 MMC 注射相比，在体外和体内均表现出显著更高的抗癌效果。这些结果表明，载丝裂霉素 C 的聚合物-脂质混合纳米颗粒可能是一种有用且高效的药物递送系统，可扩大丝裂霉素 C 的治疗窗，并使丝裂霉素 C 的临床应用更接近现实。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305a/4198073/276eeafa5b9d/1556-276X-9-560-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305a/4198073/da5c002d2ff7/1556-276X-9-560-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305a/4198073/387f9fc87c28/1556-276X-9-560-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305a/4198073/2b8f9497eb1a/1556-276X-9-560-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305a/4198073/2c71850a818b/1556-276X-9-560-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305a/4198073/6efe5a26b83b/1556-276X-9-560-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305a/4198073/276eeafa5b9d/1556-276X-9-560-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305a/4198073/da5c002d2ff7/1556-276X-9-560-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305a/4198073/387f9fc87c28/1556-276X-9-560-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305a/4198073/2b8f9497eb1a/1556-276X-9-560-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305a/4198073/2c71850a818b/1556-276X-9-560-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305a/4198073/6efe5a26b83b/1556-276X-9-560-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305a/4198073/276eeafa5b9d/1556-276X-9-560-7.jpg

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