UMR 7242 CNRS, Laboratory of Excellence Medalis, Biotechnologie et Signalisation Cellulaire, Université de Strasbourg , Illkirch , France.
Front Endocrinol (Lausanne). 2014 Oct 2;5:158. doi: 10.3389/fendo.2014.00158. eCollection 2014.
Mammalian RF-amide peptides, which all share a conserved carboxyl-terminal Arg-Phe-NH2 sequence, constitute a family of five groups of neuropeptides that are encoded by five different genes. They act through five G-protein-coupled receptors and each group of peptide binds to and activates mostly one receptor: RF-amide related peptide group binds to NPFFR1, neuropeptide FF group to NPFFR2, pyroglutamylated RF-amide peptide group to QRFPR, prolactin-releasing peptide group to prolactin-releasing peptide receptor, and kisspeptin group to Kiss1R. These peptides and their receptors have been involved in the modulation of several functions including reproduction, feeding, and cardiovascular regulation. Data from the literature now provide emerging evidence that all RF-amide peptides and their receptors are also involved in the modulation of nociception. This review will present the current knowledge on the involvement in rodents of the different mammalian RF-amide peptides and their receptors in the modulation of nociception in basal and chronic pain conditions as well as their modulatory effects on the analgesic effects of opiates.
哺乳动物 RF-酰胺肽，它们都共享一个保守的羧基末端 Arg-Phe-NH2 序列，构成了由五个不同基因编码的五组神经肽家族。它们通过五个 G 蛋白偶联受体起作用，每组肽主要与一个受体结合并激活：RF-酰胺相关肽组与 NPFFR1 结合，神经肽 FF 组与 NPFFR2 结合，焦谷氨酸化 RF-酰胺肽组与 QRFPR 结合，催乳素释放肽组与催乳素释放肽受体结合，而 kisspeptin 组与 Kiss1R 结合。这些肽及其受体参与了多种功能的调节，包括生殖、进食和心血管调节。文献中的数据现在提供了新的证据，表明所有 RF-酰胺肽及其受体也参与了伤害感受的调节。这篇综述将介绍目前在啮齿动物中不同哺乳动物 RF-酰胺肽及其受体在基础和慢性疼痛条件下对伤害感受的调节，以及它们对阿片类药物镇痛作用的调节作用的知识。
