Makni S, Ayed K, Ben Said M, Ben Rachid M S
Service d'Immunologie, Faculté de Médecine, Tunis.
Ann Trop Med Parasitol. 1989 Aug;83(4):349-55. doi: 10.1080/00034983.1989.11812356.
In the present study, sera of 56 children suffering from visceral Mediterranean leishmaniasis were analysed. The incidence of circulating immune complexes (CIC) by ELISA technique using the conglutinin binding assay was 39% before treatment, 28% after the first treatment, and nil at the end of the second one. The C4 levels remain low even after treatment. The anti-leishmania antibodies (AAL) account for 95% of the cases before treatment and 84% after treatment. The rheumatoid factor (FR) also remains with more or less the same frequency (74%) before and after treatment. The search for a correlation between the presence of CIC and the other immunological factors show that the average titre of AAL is higher in the group of patients that have CIC than in the group that does not. The C4 levels are significantly reduced in the CIC positive group of patients, whereas the rate of IgG is significantly increased in the same group. The study of the evolution of CIC under treatment in nine patients shows that they disappear at the end of the treatment, and that the FR reduces but does not disappear.
在本研究中，对56例患内脏型地中海利什曼病的儿童血清进行了分析。采用胶固素结合试验的ELISA技术检测循环免疫复合物（CIC）的发生率，治疗前为39%，首次治疗后为28%，第二次治疗结束时为零。即使在治疗后，C4水平仍保持较低。抗利什曼原虫抗体（AAL）在治疗前占病例的95%，治疗后占84%。类风湿因子（RF）在治疗前后的出现频率也大致相同（74%）。对CIC的存在与其他免疫因素之间相关性的研究表明，有CIC的患者组中AAL的平均滴度高于无CIC的患者组。CIC阳性患者组的C4水平显著降低，而同一组中的IgG水平显著升高。对9例患者治疗过程中CIC演变的研究表明，它们在治疗结束时消失，RF减少但未消失。
