色素性视网膜炎中的免疫复合物。

Immune complexes in retinitis pigmentosa.

作者信息

García-Calderón P A, Engel P, Cols N, Heredia García C D

出版信息

Ophthalmic Paediatr Genet. 1984 Dec;4(3):199-202. doi: 10.3109/13816818409006122.

Abstract

In a group of 46 patients with retinitis pigmentosa (RP), we studied the levels of IgM, the presence of a rheumatoid factor (RF), the circulating immune complexes (CIC) and the alterations in the complement system. Our results showed increased IgM levels in two patients (226 and 260 mg/dl), the presence of RF in three patients (205, 187 and 80 IU/ml), the existence of CIC in 43.5% of the subjects, reduced levels of the complement components C3 and C4 (p less than 0.001) and of the haemolytic activity CH50 (p less than 0.001) when compared with a control group consisting of 100 healthy subjects. We found a statistically significant correlation between the values of C3 and CIC (p less than 0.01), C4 and CIC (p less than 0.01) and between CH50 and CIC (p less than 0.001).

摘要

在一组46例色素性视网膜炎（RP）患者中，我们研究了IgM水平、类风湿因子（RF）的存在情况、循环免疫复合物（CIC）以及补体系统的变化。我们的结果显示，两名患者的IgM水平升高（分别为226和260mg/dl），三名患者存在RF（分别为205、187和80IU/ml），43.5%的受试者存在CIC，与由100名健康受试者组成的对照组相比，补体成分C3和C4水平降低（p<0.001），溶血活性CH50降低（p<0.001）。我们发现C3与CIC值之间（p<0.01）、C4与CIC值之间（p<0.01）以及CH50与CIC值之间（p<0.001）存在统计学显著相关性。