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阿塞那平诱发的不宁腿综合征:与静坐不能的鉴别。

Asenapine-induced restless legs syndrome: differentiation from akathisia.

作者信息

McCall W Vaughn, Riley Mary Anne, Hodges Chelsea, McCloud Laryssa, Phillips Marjorie, Rosenquist Peter B

机构信息

Department of Psychiatry and Health Behavior, The Medical College of Georgia, Georgia Regents University, Augusta, GA.

Pharmacy Department, Georgia Regents Medical Center, Augusta, GA.

出版信息

J Clin Sleep Med. 2014 Dec 15;10(12):1341-2. doi: 10.5664/jcsm.4296.

DOI:10.5664/jcsm.4296
PMID:25325577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4237529/
Abstract

Akathisia and restless legs syndrome (RLS) share some common clinical features and a common relationship with dopamine dysfunction. However, the underlying causes and appropriate treatments for akathisia and RLS are different. Herein we describe a case of RLS that was precipitated by a single dose of asenapine, which is an atypical antipsychotic, and dissect the features that support the contention that this was indeed a case of RLS and not akathisia.

摘要

静坐不能与不宁腿综合征(RLS)有一些共同的临床特征,且与多巴胺功能障碍存在共同关联。然而,静坐不能和RLS的潜在病因及恰当治疗方法有所不同。在此我们描述一例由单剂量阿立哌唑(一种非典型抗精神病药物)诱发的RLS病例,并剖析支持该病例确实为RLS而非静坐不能这一观点的特征。

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本文引用的文献

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A case of akathisia induced by escitalopram: case report & review of literature.一例由艾司西酞普兰引起的静坐不能:病例报告及文献综述
Curr Drug Saf. 2014 Mar;9(1):56-9. doi: 10.2174/157488630901140224104651.
2
Drugs associated with restless legs syndrome: a case/noncase study in the French Pharmacovigilance Database.与不宁腿综合征相关的药物:法国药物警戒数据库中的病例/非病例研究。
J Clin Psychopharmacol. 2012 Dec;32(6):824-7. doi: 10.1097/JCP.0b013e318272cdd8.
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Asenapine: a clinical review of a second-generation antipsychotic.阿塞那平:一种第二代抗精神病药物的临床评价。
Clin Ther. 2012 May;34(5):1023-40. doi: 10.1016/j.clinthera.2012.03.002. Epub 2012 Apr 10.
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Restless leg syndrome associated with olanzapine: a case series.奥氮平相关的不宁腿综合征:病例系列
Curr Drug Saf. 2010 Apr;5(2):129-31. doi: 10.2174/157488610790936187.
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Akathisia and second-generation antipsychotic drugs.静坐不能与第二代抗精神病药物
Curr Opin Psychiatry. 2009 May;22(3):293-99. doi: 10.1097/yco.0b013e32832a16da.
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Definition of restless legs syndrome, how to diagnose it, and how to differentiate it from RLS mimics.不宁腿综合征的定义、如何诊断以及如何将其与类似不宁腿综合征的情况相鉴别。
Mov Disord. 2007;22 Suppl 18:S401-8. doi: 10.1002/mds.21604.
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Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding.支持不安腿综合征中多巴胺能活性低下:一项关于 D2 受体结合的正电子发射断层扫描研究。
Brain. 2006 Aug;129(Pt 8):2017-28. doi: 10.1093/brain/awl163. Epub 2006 Jul 1.
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Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health.不宁腿综合征:诊断标准、特殊考量及流行病学。美国国立卫生研究院不宁腿综合征诊断与流行病学研讨会报告
Sleep Med. 2003 Mar;4(2):101-19. doi: 10.1016/s1389-9457(03)00010-8.