Aggarwal Shilpa, Dodd Seetal, Berk Michael
Orygen Research Centre, Parkville, Victoria, Australia.
Curr Drug Saf. 2015;10(2):98-105. doi: 10.2174/1574886309666140527114159.
Restless leg syndrome (RLS) is a common disorder, frequently of unclear origin, which is often associated with significant distress. There are a few case reports of atypical antipsychotic agents (AAP) causing RLS. The pathophysiological mechanisms resulting in emergence of these movements suggest central dopaminergic dysfunction. Dopamine agonists and L-dopa reduce the symptoms of RLS, and some agents that block the dopaminergic system aggravate RLS. Genetic influences are implicated in RLS and an association between gene polymorphisms and antipyschotic-associated onset of RLS has been postulated. Greater awareness of potential causes of RLS, and its differentiation from akathisia and illness related agitation might help in reducing the distress associated with it and improving patient compliance in patients using atypical antipsychotic agents.
不宁腿综合征（RLS）是一种常见病症，病因常常不明，常伴有明显痛苦。有一些关于非典型抗精神病药物（AAP）导致RLS的病例报告。导致这些运动出现的病理生理机制提示中枢多巴胺能功能障碍。多巴胺激动剂和左旋多巴可减轻RLS症状，而一些阻断多巴胺能系统的药物会加重RLS。遗传因素与RLS有关，并且推测基因多态性与抗精神病药物相关的RLS发病之间存在关联。提高对RLS潜在病因的认识，以及将其与静坐不能和疾病相关的激越相鉴别，可能有助于减轻与之相关的痛苦，并提高使用非典型抗精神病药物患者的依从性。
