Guglielmo Flavius F, Mitchell Donald G, O'Kane Patrick L, Deshmukh Sandeep P, Roth Christopher G, Burach Ilene, Burns Aaron, Dulka Susan, Parker Laurence
Department of Radiology, Thomas Jefferson University, 132 South 10th Street, Philadelphia, PA, 19107, USA,
Abdom Imaging. 2015 Jun;40(5):1150-6. doi: 10.1007/s00261-014-0258-y.
The purpose of this study was to evaluate whether affected bowel in Crohn's disease patients can be identified by observing decreased peristalsis (frozen bowel sign) using cine balanced steady-state free precession (cine BSSFP) images.
5 radiologists independently reviewed cine BSSFP sequences from randomized MR Enterography (MRE) exams for 30 normal and 30 Crohn's disease patients, graded overall small bowel peristalsis from slowest to fastest, and graded peristalsis for the most abnormal small bowel segment. Sensitivity and specificity of the frozen bowel sign for diagnosing Crohn's disease were calculated. T tests of the peristalsis difference between abnormal segments and overall small bowel were conducted.
For 5 readers, the sensitivity and specificity of cine BSSFP of the frozen bowel sign for diagnosing Crohn's disease ranged from 70% to 100% and 87% to 100%, respectively. There were significant differences in peristalsis between abnormal small bowel segments and the overall small bowel for Crohn's patients, but not in the overall small bowel between normal-MRE patients and Crohn's disease patients.
Abnormal Crohn's small bowel segments have significantly decreased peristalsis compared to normal small bowel, which can be identified using cine BSSFP sequences as the frozen bowel sign.
本研究旨在评估通过使用电影平衡稳态自由进动（cine BSSFP）图像观察蠕动减弱（肠管冻结征），能否识别克罗恩病患者受累的肠管。
5名放射科医生独立回顾了30名正常人和30名克罗恩病患者随机磁共振小肠造影（MRE）检查的cine BSSFP序列，将小肠整体蠕动从最慢到最快进行分级，并对最异常的小肠段蠕动进行分级。计算肠管冻结征诊断克罗恩病的敏感性和特异性。对异常段与小肠整体之间的蠕动差异进行t检验。
对于5名阅片者，cine BSSFP肠管冻结征诊断克罗恩病的敏感性和特异性分别为70%至100%和87%至100%。克罗恩病患者异常小肠段与小肠整体之间的蠕动存在显著差异，但正常MRE患者与克罗恩病患者小肠整体之间无显著差异。
与正常小肠相比，克罗恩病异常小肠段的蠕动明显减弱，可通过cine BSSFP序列作为肠管冻结征来识别。
