Lo Kuan Emma, Ziegler Steven F
Immunology Program, Benaroya Research Institute, Seattle, WA 98101.
Immunology Program, Benaroya Research Institute, Seattle, WA 98101
J Immunol. 2014 Nov 1;193(9):4283-8. doi: 10.4049/jimmunol.1400864.
Originally shown to promote the growth and activation of B cells, thymic stromal lymphopoietin (TSLP) is now known to have wide-ranging effects on both hematopoietic and nonhematopoietic cell lineages. These include dendritic cells, basophils, mast cells, B cells, epithelial cells, and CD4(+), CD8(+), and NK T cells. Although TSLP's role in the promotion of Th2 responses has been studied extensively in the context of lung- and skin-specific allergic disorders, it is becoming increasingly clear that TSLP may impact multiple disease states within multiple organ systems. This review highlights recent advances in the understanding of the surprising role of TSLP in the control of a variety of cancers, both solid tumors and leukemia, in which the TSLP/TSLP receptor axis was shown to be an important regulator.
胸腺基质淋巴细胞生成素（TSLP）最初被证明可促进B细胞的生长和活化，现在已知它对造血和非造血细胞谱系都有广泛影响。这些细胞包括树突状细胞、嗜碱性粒细胞、肥大细胞、B细胞、上皮细胞以及CD4(+)、CD8(+)和自然杀伤T细胞。尽管TSLP在促进Th2反应中的作用已在肺部和皮肤特异性过敏性疾病的背景下得到广泛研究，但越来越清楚的是，TSLP可能影响多个器官系统中的多种疾病状态。这篇综述重点介绍了在理解TSLP在控制各种癌症（包括实体瘤和白血病）中令人惊讶的作用方面的最新进展，其中TSLP/TSLP受体轴被证明是一个重要的调节因子。
