Mathieu Patrick, Boulanger Marie-Chloé, Després Jean-Pierre
Institut de Cardiologie et de Pneumologie de Québec/Quebec Heart and Lung Institute, 2725 Chemin Ste-Foy, Québec, QC, G1V-4G5, Canada,
Rev Endocr Metab Disord. 2014 Dec;15(4):289-98. doi: 10.1007/s11154-014-9299-3.
Worldwide, cardiovascular diseases (CVDs) are a leading cause of mortality. While in many westernized societies there has been a decrease prevalence of smoking and that a special emphasis has been put on the urgency to control the, so called, classical risk factors, it is more and more recognized that there remains a residual risk, which contributes to the development of CVDs. Imaging studies conducted over two decades have highlighted that the accumulation of ectopic visceral fat is associated with a plethora of metabolic dysfunctions, which have complex and intertwined interactions and participate to the development/progression/events of many cardiovascular disorders. The contribution of visceral ectopic fat to the development of coronary artery disease (CAD) is now well established, while in the last several years emerging evidence has pointed out that accumulation of harmful ectopic fat is associated with other cardiovascular disorders such as calcific aortic valve disease (CAVD), atrial fibrillation and left ventricular dysfunction. We review herein the key molecular processes linking the accumulation of ectopic fat to the development of CVDs. We have attempted, whenever possible, to use a translational approach whereby the pathobiology processes are linked to clinical observations.
在全球范围内，心血管疾病（CVDs）是主要的死亡原因。虽然在许多西方化社会中，吸烟率有所下降，并且特别强调了控制所谓经典危险因素的紧迫性，但人们越来越认识到仍存在残余风险，这会导致心血管疾病的发生。二十多年来进行的影像学研究表明，异位内脏脂肪的积累与多种代谢功能障碍有关，这些功能障碍具有复杂且相互交织的相互作用，并参与许多心血管疾病的发生、发展和事件。内脏异位脂肪对冠状动脉疾病（CAD）发生的作用现已得到充分证实，而在过去几年中，新出现的证据指出，有害异位脂肪的积累与其他心血管疾病有关，如钙化性主动脉瓣疾病（CAVD）、心房颤动和左心室功能障碍。我们在此回顾将异位脂肪积累与心血管疾病发生联系起来的关键分子过程。只要有可能，我们都尝试采用一种转化方法，将病理生物学过程与临床观察联系起来。
