Furukawa Y, Inoue T, Yamane T, Hiyoshi M, Sasaki A, Kishida T, Kojima K, Im T, Tatsumi N, Okuda K
Rinsho Byori. 1989 Jul;37(7):830-4.
Adult T-cell leukemia (ATL) cells usually express the helper/inducer associated antigen OKT 4 with lack of OKT8. However, there are a few case reports indicating that there are atypical cell phenotypes in ATL including OKT4+/OKT8+. The analysis of surface phenotype of peripheral lymphocytes and abnormal cells in lymph node was done with monoclonal antibodies. ATL cells of peripheral blood and small lymphocytes of lymph node had the usual phenotype, OKT4+/OKT8-, but neoplastic cells of large lymphocytes of lymph node had the unusual phenotype OKT4+/OKT8+. The neoplastic cells were immunophenotyped by two-color flow cytometry analysis. OKT4+/OKT8- cells had a helper cell phenotype. OKT4+/OKT8+ cells had a helper cell and a cytotoxic cell. These findings suggest that in this case ATL cells arise from common thymocyte and one of them mature in peripheral blood other remain in lymph node.
成人T细胞白血病（ATL）细胞通常表达与辅助/诱导相关的抗原OKT 4，而缺乏OKT8。然而，有一些病例报告表明，ATL中存在非典型细胞表型，包括OKT4+/OKT8+。使用单克隆抗体对外周淋巴细胞和淋巴结中的异常细胞进行表面表型分析。外周血的ATL细胞和淋巴结中的小淋巴细胞具有常见表型，即OKT4+/OKT8-，但淋巴结中大淋巴细胞的肿瘤细胞具有异常表型OKT4+/OKT8+。通过双色流式细胞术分析对肿瘤细胞进行免疫表型分析。OKT4+/OKT8-细胞具有辅助细胞表型。OKT4+/OKT8+细胞具有辅助细胞和细胞毒性细胞表型。这些发现表明，在该病例中，ATL细胞起源于普通胸腺细胞，其中一部分在外周血中成熟，另一部分留在淋巴结中。
