State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000 (China).
Angew Chem Int Ed Engl. 2014 Dec 15;53(51):14128-31. doi: 10.1002/anie.201406786. Epub 2014 Oct 19.
The development of a direct vinylogous Michael addition of linear nucleophilic substrates is a long-standing challenge because of the poor reactivity and the considerable difficulty in controlling regioselectivity. By employing a rationally designed multifunctional supramolecular iminium catalysis strategy, the first direct vinylogous Michael addition of unmodified linear substrates to α,β-unsaturated aldehydes, to afford chiral 1,7-dioxo compounds with good yields and excellent regio- as well as enantioselectivity, has been developed.
发展线性亲核底物的直接 vinylogous Michael 加成是一个长期存在的挑战，因为其反应性差且对区域选择性的控制相当困难。通过采用合理设计的多功能超分子亚胺催化策略，首次实现了未经修饰的线性底物与α,β-不饱和醛的直接 vinylogous Michael 加成，以高收率和优异的区域及对映选择性得到手性 1,7-二酮化合物。
