18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描成像对喉鳞状细胞癌包膜外扩散的效能
Efficacy of 18F-fluorodeoxyglucose positron emission tomography/CT imaging for extracapsular spread of laryngeal squamous cell carcinoma.
作者信息
Chun Byung-Joon, Yoo Ie-Ryung, Joo Young-Hoon, Nam Inn-Chul, Cho Jung-Hae, Kim Chung-Su, Cho Kwang-Jae, Kim Min-Sik
机构信息
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Nuclear Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
出版信息
Head Neck. 2016 Feb;38(2):290-3. doi: 10.1002/hed.23889. Epub 2015 Jun 15.
BACKGROUND
We evaluated the use of fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT for the identification of extracapsular spread (ECS) with supporting histologic correlations in laryngeal cancer.
METHODS
We reviewed the medical records of 89 patients with laryngeal cancer who underwent FDG PET/CT before surgery.
RESULTS
ECS was present in 38.2% (18 of 47) of dissected necks and in 32.2% (20 of 62) of dissected cervical levels. There was a significant difference in the standardized uptake value maximum (SUVmax ) between cervical lymph nodes with and without ECS (6.39 ± 4.53 vs 1.21 ± 1.70; p < .001); the cutoff value for differentiating nodes with ECS from those without ECS was 2.8, with a sensitivity of 85.7% and specificity of 85.6%.
CONCLUSION
A median SUVmax cutoff value >2.8 was associated with an increased risk of cervical lymph node metastasis and ECS in patients with laryngeal cancer.
背景
我们评估了氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）/计算机断层扫描（CT）在喉癌中识别包膜外扩散（ECS）并结合支持性组织学相关性的应用。
方法
我们回顾了89例术前接受FDG PET/CT检查的喉癌患者的病历。
结果
在47例接受清扫的颈部中，38.2%（18例）存在ECS；在62个接受清扫的颈部区域中，32.2%（20个）存在ECS。有ECS和无ECS的颈部淋巴结之间的最大标准化摄取值（SUVmax）存在显著差异（6.39±4.53 vs 1.21±1.70；p<.001）；区分有ECS和无ECS淋巴结的临界值为2.8，敏感性为85.7%，特异性为85.6%。
结论
中位SUVmax临界值>2.8与喉癌患者颈部淋巴结转移和ECS风险增加相关。
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