Abdallah J, Maradey-Romero C, Lewis S, Perzynski A, Fass R
Division of Gastroenterology and Hepatology, The Esophageal and Swallowing Center, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.
Aliment Pharmacol Ther. 2015 Jan;41(1):137-44. doi: 10.1111/apt.12991. Epub 2014 Oct 17.
Length of Barrett's oesophagus (BE) is a risk factor for oesophageal cancer. The underlying mechanisms that determine BE length are nor fully known.
To determine if there is a correlation between obesity and length of BE.
Using a population-based study, 381 patients diagnosed with Barrett's oesophagus between 1999 and 2013 were included. Body mass index (BMI) at the time of BE diagnosis was calculated. Upper endoscopy reports were reviewed to obtain the length of BE. Spearman's correlation coefficient was performed to assess the strength of the relationship between Barrett's length and BMI. A multivariate logistic regression analysis was conducted to further examine the association between BMI and length of BE.
The adjusted odds ratio for each five-point increase in BMI was 1.5 (95% CI 1.24-1.81, P < 0.001). The mean BMI was significantly higher in patients with long segment BE as compared to patients with short segment BE (32.7 vs. 30.3, P = 0.001). There was also a positive trend in long segment BE as patients entered into higher BMI categories (Z = 4.25, P < 0.001). There was a significant correlation between BMI and length of BE (r = 0.25, P < 0.0001).
The study demonstrated a correlation between BMI and the length of Barrett's oesophagus mucosa. Thus, increased BMI is associated with longer segment of Barrett's oesophagus.
巴雷特食管（BE）的长度是食管癌的一个危险因素。决定BE长度的潜在机制尚未完全明确。
确定肥胖与BE长度之间是否存在相关性。
采用基于人群的研究，纳入了1999年至2013年间诊断为巴雷特食管的381例患者。计算BE诊断时的体重指数（BMI）。回顾上消化道内镜检查报告以获取BE的长度。采用Spearman相关系数评估巴雷特食管长度与BMI之间关系的强度。进行多因素逻辑回归分析以进一步研究BMI与BE长度之间的关联。
BMI每增加5个单位的调整优势比为1.5（95%可信区间1.24 - 1.81，P < 0.001）。与短段BE患者相比，长段BE患者的平均BMI显著更高（32.7对30.3，P = 0.001）。随着患者进入更高的BMI类别，长段BE也呈现出上升趋势（Z = 4.25，P < 0.001）。BMI与BE长度之间存在显著相关性（r = 0.25，P < 0.0001）。
该研究表明BMI与巴雷特食管黏膜长度之间存在相关性。因此，BMI升高与更长的巴雷特食管段相关。
