纳米组装功能的整合用于癌症药物的有效递药级联。
Integration of nanoassembly functions for an effective delivery cascade for cancer drugs.
机构信息
Center for Bionanoengineering and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China, 310027; Department of Chemical Engineering, University of Wyoming, Laramie, WY, USA, 82071.
出版信息
Adv Mater. 2014 Dec 3;26(45):7615-21. doi: 10.1002/adma.201401554. Epub 2014 Oct 18.
A "cluster-bomb"-like lipid-dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the tumor, it releases small dendrimers that act like "bomblets", enabling tumor penetration, cell internalization, and drug release.
一种类似集束炸弹的脂质树状大分子纳米组装体协同了其各组成部分的功能，从而高效地实现了药物传递级联，以实现癌症的高效治疗。该纳米组装体在血液中成功循环并在肿瘤中积累。一旦进入肿瘤，它就会释放出类似“小炸弹”的小树状大分子，从而实现肿瘤穿透、细胞内化和药物释放。
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