Teuber S, Köhler M
Zahn Mund Kieferheilkd Zentralbl. 1989;77(7):692-7.
The value of evidence of pretherapeutic investigations with the leucocyte adherence inhibition assay (LAI) for 5-year prognosis we examined in 42 patients with malignant tumors of the maxillo-facial region. We found a tendency of higher frequency of recurrence in patients with preoperative positive LAI, but this was not statistically significant. In 19 patients we accomplished follow-up studies until 20 months after operation. Here we found no false-positive LAI, so that a positive LAI indicated always a tumor recurrence (33% of patients with recurrence), but two thirds of patients with recurrence reacted negative. In conclusion the LAI is of too small sensitivity and of too high expense.
我们用白细胞粘附抑制试验(LAI)对42例颌面恶性肿瘤患者进行了术前检查,以探讨其对5年预后的评估价值。我们发现术前LAI阳性的患者复发频率有升高趋势,但差异无统计学意义。我们对19例患者进行了术后20个月的随访研究。在此研究中,我们未发现LAI假阳性情况,因此LAI阳性总是提示肿瘤复发(复发患者中33%),但三分之二的复发患者LAI反应为阴性。总之,LAI敏感性过低且费用过高。