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下颌原发性平滑肌肉瘤

Primary leiomyosarcoma of the mandible.

作者信息

Moghadam Saede Atarbashi, Khodayari Abbas, Mokhtari Sepideh

机构信息

Department of Oral and Maxillofacial Pathology, Dental School of Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Department of Oral and Maxillofacial Surgery, Dental School of Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

J Oral Maxillofac Pathol. 2014 May;18(2):308-11. doi: 10.4103/0973-029X.140915.

DOI:10.4103/0973-029X.140915
PMID:25328319
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4196307/
Abstract

Leiomyosarcoma (LMS) is a malignant soft tissue tumor that exhibits smoothmuscle differentiation. Its occurrence in the oral cavity is exceedingly rare. This article presents a 67-year-old woman with 9-month history of a painful tumoral lesion on the right side of mandible. Tumor was composed of fascicles of spindle-shaped cells with cigar-shaped nuclei and eosinophilic cytoplasm. Immunohistochemistry showed that tumor cells were positive for smooth muscle actin (SMA) and desmin. The findings were consistent with the diagnosis of LMS.

摘要

平滑肌肉瘤(LMS)是一种表现出平滑肌分化的恶性软组织肿瘤。它在口腔中的发生极为罕见。本文介绍了一名67岁女性,其右侧下颌骨有一个疼痛性肿瘤病变,病史9个月。肿瘤由梭形细胞束组成,细胞核呈雪茄状,细胞质嗜酸性。免疫组织化学显示肿瘤细胞平滑肌肌动蛋白(SMA)和结蛋白呈阳性。这些发现与LMS的诊断一致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/68917c3f33fb/JOMFP-18-308-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/9010df5518b1/JOMFP-18-308-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/f60d10e28380/JOMFP-18-308-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/5476969a57f5/JOMFP-18-308-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/6f537d52597d/JOMFP-18-308-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/ea0cc43efe27/JOMFP-18-308-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/5ebbfc81def2/JOMFP-18-308-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/26a65d4b848d/JOMFP-18-308-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/26a65d4b848d/JOMFP-18-308-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/e6b00252a64d/JOMFP-18-308-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/68917c3f33fb/JOMFP-18-308-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/9010df5518b1/JOMFP-18-308-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/f60d10e28380/JOMFP-18-308-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/5476969a57f5/JOMFP-18-308-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/6f537d52597d/JOMFP-18-308-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/ea0cc43efe27/JOMFP-18-308-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/5ebbfc81def2/JOMFP-18-308-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/26a65d4b848d/JOMFP-18-308-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/26a65d4b848d/JOMFP-18-308-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/e6b00252a64d/JOMFP-18-308-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabd/4196307/68917c3f33fb/JOMFP-18-308-g010.jpg

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本文引用的文献

1
High-grade primary leiomyosarcoma in the mandible: diagnosis and treatment.下颌骨高级别原发性平滑肌肉瘤:诊断与治疗。
Head Neck. 2013 Feb;35(2):E44-8. doi: 10.1002/hed.21853. Epub 2011 Nov 3.
2
Metastatic uterine leiomyosarcoma to the submandibular gland.子宫平滑肌肉瘤转移至下颌下腺。
Ann Diagn Pathol. 2009 Jun;13(3):208-11. doi: 10.1016/j.anndiagpath.2008.03.001. Epub 2008 Jul 7.
3
Low-grade gingival leiomyosarcoma in a child.儿童低度恶性牙龈平滑肌肉瘤
J Dent Child (Chic). 2008 Sep-Dec;75(3):301-5.
4
Leiomyosarcoma of the buccal mucosa: a case report with immunohistochemistry findings.颊黏膜平滑肌肉瘤:一例伴有免疫组化结果的病例报告
J Oral Sci. 2008 Jun;50(2):215-8. doi: 10.2334/josnusd.50.215.
5
Primary leiomyosarcoma of the mandible. A case report.下颌原发性平滑肌肉瘤。病例报告。
Med Oral Patol Oral Cir Bucal. 2007 Jan 1;12(1):E56-9.
6
Oral leiomyosarcoma: review of the literature and report of two cases with assessment of the prognostic and diagnostic significance of immunohistochemical and molecular markers.口腔平滑肌肉瘤:文献综述及两例病例报告,并评估免疫组化和分子标志物的预后及诊断意义
Oral Oncol. 2002 Feb;38(2):201-8. doi: 10.1016/s1368-8375(01)00047-1.
7
Primary intraoral leiomyosarcoma of the tongue: an immunohistochemical study and review of the literature.舌原发性口腔平滑肌肉瘤:一项免疫组织化学研究及文献综述
Oral Oncol. 2000 Nov;36(6):519-24. doi: 10.1016/s1368-8375(00)00044-0.
8
Leiomyosarcomas of the oral cavity: an unusual topographic subset easily mistaken for nonmesenchymal tumours.口腔平滑肌肉瘤:一种易被误诊为非间叶性肿瘤的特殊部位亚型。
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9
[Leiomyosarcoma of the mandibular canal. Possible differential diagnosis of cystic processes of the mandible].[下颌管平滑肌肉瘤。下颌骨囊性病变的可能鉴别诊断]
Mund Kiefer Gesichtschir. 1998 Jan;2(1):42-3. doi: 10.1007/s100060050027.