Bhargava Rahul, Kumar Prachi, Kaur Avinash, Kumar Manjushri, Mishra Anurag
Department of Ophthalmology, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India.
Department of Pathology, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India.
J Lab Physicians. 2014 Jul;6(2):102-8. doi: 10.4103/0974-2727.141507.
To compare the diagnostic value and accuracy of dry eye scoring system (DESS), conjunctival impression cytology (CIC), tear film breakup time (TBUT), and Schirmer's test in computer users.
A case-control study was done at two referral eye centers. Eyes of 344 computer users were compared to 371 eyes of age and sex matched controls. Dry eye questionnaire (DESS) was administered to both groups and they further underwent measurement of TBUT, Schirmer's, and CIC. Correlation analysis was performed between DESS, CIC, TBUT, and Schirmer's test scores. A Pearson's coefficient of the linear expression (R (2)) of 0.5 or more was statistically significant.
The mean age in cases (26.05 ± 4.06 years) was comparable to controls (25.67 ± 3.65 years) (P = 0.465). The mean symptom score in computer users was significantly higher as compared to controls (P < 0.001). Mean TBUT, Schirmer's test values, and goblet cell density were significantly reduced in computer users (P < 0.001). TBUT, Schirmer's, and CIC were abnormal in 48.5%, 29.1%, and 38.4% symptomatic computer users respectively as compared to 8%, 6.7%, and 7.3% symptomatic controls respectively. On correlation analysis, there was a significant (inverse) association of dry eye symptoms (DESS) with TBUT and CIC scores (R (2) > 0.5), in contrast to Schirmer's scores (R(2) < 0.5). Duration of computer usage had a significant effect on dry eye symptoms severity, TBUT, and CIC scores as compared to Schirmer's test.
DESS should be used in combination with TBUT and CIC for dry eye evaluation in computer users.
比较干眼评分系统（DESS）、结膜印迹细胞学检查（CIC）、泪膜破裂时间（TBUT）和施密特试验在计算机使用者中的诊断价值和准确性。
在两个转诊眼科中心进行了一项病例对照研究。将344名计算机使用者的眼睛与371名年龄和性别匹配的对照者的眼睛进行比较。两组均进行干眼问卷调查（DESS），并进一步接受TBUT、施密特试验和CIC测量。对DESS、CIC、TBUT和施密特试验得分进行相关性分析。线性表达式的Pearson系数（R（2））为0.5或更高具有统计学意义。
病例组的平均年龄（26.05±4.06岁）与对照组（25.67±3.65岁）相当（P = 0.465）。计算机使用者的平均症状评分显著高于对照组（P < 0.001）。计算机使用者的平均TBUT、施密特试验值和杯状细胞密度显著降低（P < 0.001）。有症状的计算机使用者中，TBUT、施密特试验和CIC异常的比例分别为48.5%、29.1%和38.4%，而有症状的对照组分别为8%、6.7%和7.3%。相关性分析显示，干眼症状（DESS）与TBUT和CIC得分存在显著（负）关联（R（2）> 0.5），与施密特试验得分相反（R（2）< 0.5）。与施密特试验相比，计算机使用时间对干眼症状严重程度、TBUT和CIC得分有显著影响。
在对计算机使用者进行干眼评估时，应将DESS与TBUT和CIC联合使用。
