Uchino Miki, Schaumberg Debra A, Dogru Murat, Uchino Yuichi, Fukagawa Kazumi, Shimmura Shigeto, Satoh Toshihiko, Takebayashi Toru, Tsubota Kazuo
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan; Ryogoku Eye Clinic, Tokyo, Japan.
Ophthalmology. 2008 Nov;115(11):1982-8. doi: 10.1016/j.ophtha.2008.06.022. Epub 2008 Aug 16.
To determine the prevalence of dry eye disease (DED) and risk factors among young and middle-aged Japanese office workers using visual display terminals (VDTs).
Cross-sectional prevalence survey.
Four thousand three hundred ninety-three Japanese young and middle-aged office workers using VDTs.
Office workers completed questionnaires sent by e-mail designed to detect dry eye diagnosis and risk factors.
Clinically diagnosed DED was defined as the presence of a previous clinical diagnosis of DED by dry eye specialists or severe symptoms of DED (both dryness and irritation constantly or often). Current symptoms of DED and possible risk factors such as age, duration of VDT use, type of VDT work, environmental factors, presence of systemic diseases, systemic medicine use, smoking history, and contact lens (CL) use were the main outcome measures. We used logistic regression to examine associations between DED and other demographic factors.
Of the 4393 office workers, 3549 (80.1%) completed the questionnaire. Clinically diagnosed DED was present in 266 (10.1%) of 2640 male subjects and in 195 (21.5%) of 909 female subjects. Severe symptoms of DED were observed in 711 male and in 436 female participants. More than 4 hours of VDT use was associated with an increased risk of DED (odds ratio [OR], 1.68; 95% confidence interval [CI], 1.40-2.02). In addition, CL use (OR, 3.91; 95% CI, 3.37-4.53) increased the risk of severe dry eye symptoms.
Dry eye disease leading to a clinical diagnosis or severe symptoms is prevalent among young and middle-aged Japanese office workers. The condition is more prevalent among females, CL wearers, and prolonged VDT users. Relevant measures directed against the modifiable risks could provide a positive impact on public health and quality of life of office workers.
FINANCIAL DISCLOSURE(S): The authors have no proprietary or commercial interest in any materials discussed in this article.
确定使用视觉显示终端(VDT)的日本中青年上班族中干眼症(DED)的患病率及危险因素。
横断面患病率调查。
4393名使用VDT的日本中青年上班族。
上班族通过电子邮件完成旨在检测干眼症诊断及危险因素的问卷。
临床诊断的DED定义为曾有干眼症专科医生的临床诊断或有严重的DED症状(持续或经常出现干涩和刺激感)。DED的当前症状以及年龄、VDT使用时长、VDT工作类型、环境因素、全身性疾病的存在、全身用药、吸烟史和隐形眼镜(CL)使用等可能的危险因素为主要观察指标。我们采用逻辑回归分析来研究DED与其他人口统计学因素之间的关联。
在4393名上班族中,3549人(80.1%)完成了问卷。在2640名男性受试者中,266人(10.1%)有临床诊断的DED;在909名女性受试者中,195人(21.5%)有临床诊断的DED。711名男性和436名女性参与者有严重的DED症状。VDT使用时长超过4小时与DED风险增加相关(比值比[OR]为1.68;95%置信区间[CI]为1.40 - 2.02)。此外,使用CL(OR为3.91;95%CI为3.37 - 4.53)会增加严重干眼症状的风险。
导致临床诊断或严重症状的干眼症在日本中青年上班族中普遍存在。这种情况在女性、佩戴CL者和VDT长期使用者中更为普遍。针对可改变风险采取的相关措施可能会对上班族的公共健康和生活质量产生积极影响。
作者对本文讨论的任何材料均无专有或商业利益。