Tadini G, Cerri A, Crosti L, Cattoretti G, Berti E
1st Department of Dermatology, University of Milan, Italy.
Acta Derm Venereol Suppl (Stockh). 1989;146:33-5.
Activity of p53, H-ras, c-myc and c-fos in psoriatic lesions was studied using monoclonal antibodies (MoAbs) performing a sensitive immunohistochemical method on frozen sections. Normal skin from surgery was used as control. Reactivity of p53, H-ras and c-myc is remarkable in psoriatic plaques but, in contrast, c-fos expression does not show differences compared to control skin. These findings led us to speculate about the importance of cellular oncogenes in the pathogenesis of psoriasis.
利用单克隆抗体（MoAbs）对冷冻切片进行敏感的免疫组织化学方法，研究了银屑病皮损中p53、H-ras、c-myc和c-fos的活性。手术获取的正常皮肤用作对照。p53、H-ras和c-myc在银屑病斑块中的反应性显著，但相比之下，与对照皮肤相比，c-fos表达没有差异。这些发现使我们推测细胞癌基因在银屑病发病机制中的重要性。
