Nagayama Tomomi, Hirooka Yoshitaka, Chishaki Akiko, Takemoto Masao, Mukai Yasushi, Inoue Shujiro, Kishi Takuya, Sunagawa Kenji
Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Department of Advanced Cardiovascular Regulation and Therapeutics, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Int J Hypertens. 2014;2014:980505. doi: 10.1155/2014/980505. Epub 2014 Sep 25.
Objective. Many previous clinical studies have suggested that atrial fibrillation (AF) is closely associated with hypertension. However, the benefits of antihypertensive therapy on AF are still inconsistent, and it is necessary to explore the factors augmenting AF in hypertensive rats. The aim of the present study was to investigate the correlation between arterial pressure or voltage stimulus and to the duration of electrically induced AF in normotensive or hypertensive rats. Methods. AF was reproducibly induced by transesophageal atrial burst pacing in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). We did the burst pacing at high (20 V) or low (5 V) voltage. Results. Duration of AF did not correlate with systolic blood pressure (SBP) and stimulus voltage in WKY. However, only in SHR, duration of AF with high stimulus voltage significantly correlated with SBP and was significantly longer in high than in low voltage stimulus. Discussion and Conclusion. Duration of AF is augmented by high voltage stimulus with higher blood pressure in SHR.
目的。此前许多临床研究表明，心房颤动（AF）与高血压密切相关。然而，抗高血压治疗对房颤的益处仍不一致，有必要探究高血压大鼠中加剧房颤的因素。本研究的目的是调查正常血压或高血压大鼠的动脉压或电压刺激与电诱导房颤持续时间之间的相关性。方法。通过经食管心房猝发起搏在自发性高血压大鼠（SHR）和Wistar - Kyoto大鼠（WKY）中可重复性地诱导房颤。我们在高（20V）或低（5V）电压下进行猝发起搏。结果。在WKY中，房颤持续时间与收缩压（SBP）和刺激电压无关。然而，仅在SHR中，高刺激电压下的房颤持续时间与SBP显著相关，且高电压刺激下的房颤持续时间明显长于低电压刺激。讨论与结论。在SHR中，高电压刺激和较高血压会增加房颤持续时间。
