Mount Sinai School of Medicine, Medicine (111), James J. Peters VA Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA.
Curr Cardiol Rep. 2009 Nov;11(6):430-5. doi: 10.1007/s11886-009-0062-4.
Atrial fibrillation (AF) is an emerging public health problem. The most important risk factor for developing chronic AF is uncontrolled hypertension. Uncontrolled hypertension promotes the initiation and perpetuation of AF through atrial remodeling. Experimental evidence has demonstrated the important role of the renin-angiotensin system in atrial remodeling. Retrospective analysis of several large clinical trials and small prospective trials suggests the beneficial role of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in preventing the onset and recurrence of AF in different populations. Several large prospective trials with longer follow-up periods are in progress. These trials may provide definitive evidence for the use of these agents in the prevention of AF.
心房颤动（AF）是一个日益严重的公共卫生问题。发生慢性 AF 的最重要的危险因素是未得到控制的高血压。未得到控制的高血压通过心房重构促进 AF 的发生和持续。实验证据已经证明了肾素-血管紧张素系统在心房重构中的重要作用。几项大型临床试验和小型前瞻性试验的回顾性分析表明，血管紧张素转换酶抑制剂和血管紧张素受体阻滞剂在预防不同人群 AF 的发生和复发方面具有有益作用。目前正在进行几项随访时间更长的大型前瞻性试验。这些试验可能为这些药物在预防 AF 中的应用提供明确的证据。
