已知患有冠状动脉疾病的印度人中炎症细胞因子与传统和非传统心血管危险因素的关联
Association of Inflammatory Cytokines with Traditional and Nontraditional Cardiovascular Risk Factors in Indians with known Coronary Artery Disease.
作者信息
Mahalle N, Garg Mk, Kulkarni Mv, Naik Ss
机构信息
Department of Pathology, Biochemistry Section, Deenanath Mangeshkar Hospital and Research Center, Erandwane, Pune, Maharashtra, India.
Department of Endocrinology, Command Hospital (Southern Command), Pune, Maharashtra, India.
出版信息
Ann Med Health Sci Res. 2014 Sep;4(5):706-12. doi: 10.4103/2141-9248.141525.
BACKGROUND
Inflammatory processes are implicated in the etiology of cardiovascular disease (CVD). Data on the association of inflammatory markers with cardiovascular risk factors in Indian patients with CVD are limited.
AIM
This study was conducted with the aim to evaluate the association of inflammatory markers with traditional and nontraditional cardiovascular risk factors in angiographically proven coronary artery disease (CAD) patients.
SUBJECTS AND METHODS
We studied the association of serum highly sensitive C-reactive protein (hsCRP) (0.1-37.9 mg/l), interleukin-6 (IL-6) (2-253.2 pg/ml) and tumor necrosis factor-alpha (TNF-α) (8-525.8 pg/ml) with cardiovascular risk factors in 300 (M: 216, F: 84; mean age: 60.9 (12.4) years) CAD patients. All patients were evaluated for anthropometry and cardiovascular risk factors, and blood samples were collected for biochemical and inflammatory markers. Statistical analysis was carried out using SPSS Version 20.
RESULTS
Mean hsCRP, IL-6 and TNF-α in study population were 11.7 (9.7) mg/l, 64.5 (75.2) pg/ml, and 25.3 (40.9) pg/ml respectively. A total of 73.6% (221/300) patients had hsCRP levels >3.0 mg/l. All inflammatory markers were significantly higher and showed a positive correlation with dyslipidemia, diabetes mellitus, and/or hypertension (HTN). TNF-α had a negative correlation with age and positive correlation with smoking. Only IL-6 and hsCRP had a positive correlation with insulin resistance and negative correlation with insulin secretion. Among lipid parameters, triglyceride had a positive correlation, and high density lipoprotein had a negative correlation with all inflammatory markers. There was a progressive increase in the percentage of subjects with diabetes, HTN, and dyslipidemia with increasing levels of inflammatory markers.
CONCLUSIONS
Indian patients with CAD had significantly high levels of inflammatory markers, which were related to cardiovascular risk factors.
背景
炎症过程与心血管疾病（CVD）的病因有关。关于印度心血管疾病患者炎症标志物与心血管危险因素之间关联的数据有限。
目的
本研究旨在评估经血管造影证实的冠心病（CAD）患者炎症标志物与传统和非传统心血管危险因素之间的关联。
研究对象与方法
我们研究了300例（男性216例，女性84例；平均年龄：60.9（12.4）岁）CAD患者血清高敏C反应蛋白（hsCRP）（0.1 - 37.9mg/L）、白细胞介素 - 6（IL - 6）（2 - 253.2pg/mL）和肿瘤坏死因子 - α（TNF - α）（8 - 525.8pg/mL）与心血管危险因素之间的关联。对所有患者进行人体测量和心血管危险因素评估，并采集血样检测生化和炎症标志物。使用SPSS 20版进行统计分析。
结果
研究人群中hsCRP、IL - 6和TNF - α的平均值分别为11.7（9.7）mg/L、64.5（75.2）pg/mL和25.3（40.9）pg/mL。共有73.6%（221/300）的患者hsCRP水平>3.0mg/L。所有炎症标志物均显著升高，且与血脂异常、糖尿病和/或高血压（HTN）呈正相关。TNF - α与年龄呈负相关，与吸烟呈正相关。只有IL - 6和hsCRP与胰岛素抵抗呈正相关，与胰岛素分泌呈负相关。在血脂参数中，甘油三酯与所有炎症标志物呈正相关，高密度脂蛋白与所有炎症标志物呈负相关。随着炎症标志物水平升高，患糖尿病、HTN和血脂异常的受试者百分比逐渐增加。
结论
印度CAD患者炎症标志物水平显著升高，且与心血管危险因素相关。
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