阿育吠陀体质类型与心血管危险因素、炎症标志物及胰岛素抵抗的关联。
Association of constitutional type of Ayurveda with cardiovascular risk factors, inflammatory markers and insulin resistance.
作者信息
Mahalle Namita P, Kulkarni Mohan V, Pendse Narendra M, Naik Sadanand S
机构信息
Department of Pathology, Deenanath Mangeshkar Hospital, Pune, Maharashatra, India.
出版信息
J Ayurveda Integr Med. 2012 Jul;3(3):150-7. doi: 10.4103/0975-9476.100186.
CONTEXT
Ayurveda propounds that diseases manifest from imbalance of doshas. There, have been attempts to indicate biochemical basis of constitutional types described in Ayurveda.
AIMS
The study was intended to assess the association of constitutional types (Prakriti) with cardiovascular risk factors, inflammatory markers and insulin resistance in subjects with coronary artery disease (CAD).
SETTINGS AND DESIGN
Hospital based cross sectional study.
MATERIALS AND METHODS
Three hundred patients with CAD >25 years were studied. Assessment of Prakriti was done by using Ayusoft software. Biochemical parameters, inflammatory markers (hsCRP, TNF-alpha and IL-6) and insulin resistance (HOMA-IR) were measured.
STATISTICAL ANALYSIS
Was done using EPI INFO, version 3.5.3.
RESULTS
Mean age of patients was 60.97±12.5 years. Triglyceride, VLDL and LDL was significantly higher (P<0.0001, P<0.0001 and 0.0355, respectively) and HDL cholesterol (P<0.0001) significantly lower in vatta kapha (VK) Prakriti when compared with other constitution type. VK Prakriti was correlated with diabetes mellitus (r=0.169, P=0.003), hypertension (r=0.211, P≤0.0001) and dyslipidemia (r=0.541, P≤0.0001). Inflammatory markers; IL6, TNF alpha, hsCRP and HOMA IR was highest in VK Prakriti. Inflammatory markers were correlated positively with both VK and Kapha group.
CONCLUSIONS
There is strong relation of risk factors (diabetes, hypertension, dyslipidemia), insulin resistance, and inflammatory markers with Vata Kapha and Kapha Prakriti.
背景
阿育吠陀医学认为疾病源于 doshas 的失衡。人们一直在尝试揭示阿育吠陀医学中所描述体质类型的生化基础。
目的
本研究旨在评估冠心病（CAD）患者的体质类型（Prakriti）与心血管危险因素、炎症标志物及胰岛素抵抗之间的关联。
设置与设计
基于医院的横断面研究。
材料与方法
对 300 例年龄大于 25 岁的 CAD 患者进行研究。使用 Ayusoft 软件评估 Prakriti。测量生化参数、炎症标志物（hsCRP、TNF-α 和 IL-6）及胰岛素抵抗（HOMA-IR）。
统计分析
使用 EPI INFO 3.5.3 版本进行分析。
结果
患者的平均年龄为 60.97±12.5 岁。与其他体质类型相比，vatta kapha（VK）体质类型的甘油三酯、极低密度脂蛋白和低密度脂蛋白显著更高（分别为 P<0.0001、P<0.0001 和 0.0355），而高密度脂蛋白胆固醇显著更低（P<0.0001）。VK 体质类型与糖尿病（r=0.169，P=0.003）、高血压（r=0.211，P≤0.0001）和血脂异常（r=0.541，P≤0.0001）相关。炎症标志物；IL6,TNF-α,hsCRP 和 HOMA-IR 在 VK 体质类型中最高。炎症标志物与 VK 和 Kapha 组均呈正相关。
结论
危险因素（糖尿病、高血压、血脂异常）、胰岛素抵抗和炎症标志物与 Vata Kapha 和 Kapha 体质类型之间存在密切关系。
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