Osiac Eugen, Bălşeanu Tudor Adrian, Mogoantă Laurenţiu, Gheonea Dan Ionuţ, Pirici Ionica, Iancău Maria, Mitran Smaranda Ioana, Albu Carmen Valeria, Cătălin Bogdan, Sfredel Veronica
Department of Functional Sciences, University of Medicine and Pharmacy of Craiova, Romania;
Rom J Morphol Embryol. 2014;55(3):767-72.
Although already in use in several medical domains, only recently optical coherence tomography (OCT) has been applied in the study of ischemic events. In this paper, we will focus on characterizing ischemic stroke, in a rat model, by OCT. Investigations were carried on a set of 25 rats, on which ischemic stroke was inflicted by a transient occlusion of the middle cerebral artery (tMCAO). Animals were sacrificed 1, 3, 7 and 28 days after occlusion. We tested the OCT's power of detection and discrimination of stroke area compared to both normal, contralateral hemisphere and non-affected brain tissue, together with the aid of histochemical and pathological examination. Our results show a great potential of OCT to be used as a detection tool in acute and chronic phases of stroke.
尽管光学相干断层扫描（OCT）已在多个医学领域中使用，但直到最近才被应用于缺血性事件的研究。在本文中，我们将重点通过OCT对大鼠模型中的缺血性中风进行特征描述。对一组25只大鼠进行了研究，通过大脑中动脉短暂闭塞（tMCAO）造成缺血性中风。在闭塞后1、3、7和28天对动物实施安乐死。我们借助组织化学和病理学检查，测试了OCT与正常对侧半球和未受影响的脑组织相比，对中风区域的检测和区分能力。我们的结果表明，OCT在中风的急性和慢性阶段用作检测工具具有巨大潜力。
