急性缺血性卒中后的血液凝固
Blood Coagulation Following an Acute Ischemic Stroke.
作者信息
Sfredel M D, Burada E, Cătălin B, Dinescu V, Târtea G, Iancău M, Osiac E
机构信息
Department of Physiology, University of Medicine and Pharmacy from Craiova, Romania.
Center of Clinical and Experimental Medicine, University of Medicine and Pharmacy from Craiova, Romania.
出版信息
Curr Health Sci J. 2018 Apr-Jun;44(2):118-121. doi: 10.12865/CHSJ.44.02.04. Epub 2018 Mar 27.
OBJECTIVE
Hemostasis is a complex physiological process that stops bleeding at the site of a vascular injury. Although the majority of vascular accidents are ischemic, the role of hypercoagulable state and stroke needs further investigation.
MATERIALS AND METHODS
Fresh whole blood was taken from 61 acute ischemic stroke patients and compared to 18 healthy subjects and investigated with optical coherence tomography imaging after initiating coagulation. We used an OCT1300SS system (Thorlabs) and did 3D scans. We then processed the images with ImageJ. For each image mean, integrated density, skewness and kurtosis of gray values were analyzed.
RESULTS
Mean gray value and integrated intensity of sampled data showed an intrinsic difference detected with OCT. This difference was further confirmed by the data distribution analysis.
CONCLUSIONS
Results suggest, that normal blood coagulation, is not a random reaction while in the case of stroke patients, the relatively symmetrical distribution of gray values brings coagulation closer randomized process.
目的
止血是一个复杂的生理过程，可在血管损伤部位阻止出血。尽管大多数血管意外是缺血性的，但高凝状态与中风之间的关系仍需进一步研究。
材料与方法
采集61例急性缺血性中风患者的新鲜全血，并与18名健康受试者的血液进行比较，在启动凝血后用光学相干断层扫描成像进行研究。我们使用了OCT1300SS系统（Thorlabs）并进行了三维扫描。然后我们用ImageJ处理图像。对每个图像的灰度值均值、积分密度、偏度和峰度进行分析。
结果
采样数据的平均灰度值和积分强度显示出光学相干断层扫描检测到的内在差异。数据分布分析进一步证实了这种差异。
结论
结果表明，正常血液凝固并非随机反应，而在中风患者中，灰度值的相对对称分布使凝血过程更接近随机过程。
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