Fresenius Medical Care Hungary, Semmelweis University, Budapest, Hungary; Carolinas Campus, Edward Via Osteopathic College of Medicine, Spartanburg, SC.
J Clin Hypertens (Greenwich). 2014 Dec;16(12):895-9. doi: 10.1111/jch.12428. Epub 2014 Oct 20.
The authors examined the relationship between thiazide-type diuretics and fluid spaces in a cohort of hypertensive patients in a retrospective study of 60 stable hypertensive patients without renal abnormalities who underwent whole-body bioimpedance analysis. Overhydration was greater in the diuretic group, but only to a nonsignificant degree (5.9 vs. 2.9%; P=.21). The total body water did not differ in the two groups (41.8 L vs. 40.5 L; P=.64). Extracellular fluid volume (ECV) (19.7 L vs. 18.5 L; P=.35) and intracellular fluid volume (ICV) spaces (20.8 L vs. 21.3 L; P=.75) were also not significantly different in the two groups. The ratio of ICV:ECV, however, appeared different: 1.05 vs 1.15 (P=.017) and the effect was maintained in the linear regression-adjusted model (β coefficient: -0.143; P=.001). The diuretic-related distortion of ICV:ECV ratio indicates potential fluid redistribution in hypertensive patients, with ICV participating in the process.
作者在一项回顾性研究中检查了 60 名稳定的高血压患者（无肾功能异常）的队列中噻嗪类利尿剂与体液腔之间的关系，这些患者接受了全身生物阻抗分析。在利尿剂组中，过度水化更为明显，但无统计学意义（5.9%比 2.9%；P=.21）。两组的总体水含量没有差异（41.8 升比 40.5 升；P=.64）。两组的细胞外液容量（ECV）（19.7 升比 18.5 升；P=.35）和细胞内液容量（ICV）空间（20.8 升比 21.3 升；P=.75）也没有明显差异。然而，ICV:ECV 的比值似乎不同：1.05 比 1.15（P=.017），并且在线性回归调整模型中保持这种效果（β系数：-0.143；P=.001）。利尿剂相关的 ICV:ECV 比值的扭曲表明高血压患者存在潜在的液体再分布，其中 ICV 参与了这一过程。
