单纯收缩期、单纯舒张期及收缩期-舒张期隐匿性高血压与颈动脉内膜中层厚度的关联
Association of isolated systolic, isolated diastolic, and systolic-diastolic masked hypertension with carotid artery intima-media thickness.
作者信息
Manios Efstathios, Michas Fotios, Stamatelopoulos Kimon, Koroboki Eleni, Stellos Konstantinos, Tsouma Iliana, Vemmos Konstantinos, Zakopoulos Nikolaos
机构信息
Department of Clinical Therapeutics, Medical School of Athens, Alexandra Hospital, Athens, Greece.
出版信息
J Clin Hypertens (Greenwich). 2015 Jan;17(1):22-6. doi: 10.1111/jch.12430. Epub 2014 Oct 20.
Masked hypertension (MH) is associated with advanced target organ damage. However, patients with MH constitute a group of individuals with heterogeneous characteristics concerning their ambulatory blood pressure (BP) status. The aim of this study was to evaluate the association of isolated systolic MH, isolated diastolic MH, and systolic/diastolic MH with carotid artery intima-media thickness (CIMT). A total of 101 patients with MH underwent carotid artery ultrasonographic measurements. The patients were divided into three groups according to office and daytime BP values: isolated systolic MH, isolated diastolic MH, and systolic/diastolic MH. Patients with isolated systolic (n=36) (0.771 mm) and systolic/diastolic MH (n=37) (0.775 mm) had significantly (P<.05) higher CIMT values than those with isolated diastolic MH (n=28) (0.664 mm), even after adjustment for baseline characteristics and risk factors. Patients with isolated systolic and systolic/diastolic MH presented significantly higher CIMT values compared with patients with isolated diastolic MH.
隐匿性高血压（MH）与靶器官损害进展相关。然而，MH患者是一组在动态血压（BP）状态方面具有异质性特征的个体。本研究的目的是评估单纯收缩期MH、单纯舒张期MH以及收缩期/舒张期MH与颈动脉内膜中层厚度（CIMT）之间的关联。共有101例MH患者接受了颈动脉超声测量。根据诊室血压和日间血压值将患者分为三组：单纯收缩期MH、单纯舒张期MH以及收缩期/舒张期MH。即使在对基线特征和危险因素进行校正后，单纯收缩期MH患者（n = 36）（CIMT为0.771 mm）和收缩期/舒张期MH患者（n = 37）（CIMT为0.775 mm）的CIMT值仍显著高于单纯舒张期MH患者（n = 28）（CIMT为0.664 mm）（P <.05）。与单纯舒张期MH患者相比，单纯收缩期和收缩期/舒张期MH患者的CIMT值显著更高。
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