[绿茶提取物对佛波酯促进作用及相关作用的抑制效应]

[Inhibitory effect of green tea extract on promotion and related action of TPA].

作者信息

Cheng S J

出版信息

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1989 Aug;11(4):259-64.

Abstract

Polyphenol components isolated from green tea showed strong antioxidant activity. The green tea extract (GTE) significantly inhibited the promoting effect of TPA in BALB/3T3 cell transformation assays. In in vivo experiments, GTE inhibited edema induced by TPA in mouse ear. The inhibitory effect of GTE on the induction of ornithine decarboxylase activity was also found in mouse skin treated with TPA. GTE decreased the frequency of SCE induced by oxygen radical in IAR 20 liver cells treated with hypoxanthine and xanthine oxidase. Mechanisms of the antipromoting effect of GTE are discussed. Our experimental results suggest that GTE may have some practical use in cancer prevention.

摘要

从绿茶中分离出的多酚成分具有很强的抗氧化活性。在BALB/3T3细胞转化试验中，绿茶提取物（GTE）显著抑制了佛波酯（TPA）的促癌作用。在体内实验中，GTE抑制了TPA诱导的小鼠耳部水肿。在用TPA处理的小鼠皮肤中也发现了GTE对鸟氨酸脱羧酶活性诱导的抑制作用。在用次黄嘌呤和黄嘌呤氧化酶处理的IAR 20肝细胞中，GTE降低了氧自由基诱导的姐妹染色单体交换（SCE）频率。本文讨论了GTE的抗促癌作用机制。我们的实验结果表明，GTE在癌症预防方面可能有一些实际用途。

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