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[肺癌脑转移瘤螺旋断层放射治疗计划中射野宽度和螺距的研究]

[Investigation of field width and pitch in tomotherapy treatment plans for brain metastases from lung cancer].

作者信息

Zhu Fuhai, Wu Weizhang, Wang Yong, Guo Jing, Wang Yingjie, Xia Tingyi

出版信息

Zhongguo Yi Liao Qi Xie Za Zhi. 2014 Jul;38(4):301-4.

Abstract

Tomotherapy plans were produced using a combination of field widths (1 cm, 2.5 cm and 5 cm) and pitches (0.15, 0.30, and 0.45) for seven patients with brain metastases from lung cancer, the plans were compared with dosimetric parameters, protection of organs at risk (OAR) dose and treatment times. All plans were defined that CTV with 30Gy and GTV 50 Gy by ten fraction synchronously. The results showed that the mean dose and CI for GTV was statistical difference (P = 0.002 1, P = 0.012 8), OARs were within the normal range, the treatment time increased inversely proportional to the jaw width, but had lesser impact on the pitch. This study showed plans produced with 5 cm jaw was an effective method for patients with brain metastases from lung cancer.

摘要

对于7例肺癌脑转移患者,采用不同的射野宽度(1 cm、2.5 cm和5 cm)和螺距(0.15、0.30和0.45)组合生成断层放疗计划,并将这些计划与剂量学参数、危及器官(OAR)剂量保护及治疗时间进行比较。所有计划均定义为同步分10次给予临床靶体积(CTV)30 Gy和大体肿瘤体积(GTV)50 Gy。结果显示,GTV的平均剂量和适形指数存在统计学差异(P = 0.002 1,P = 0.012 8),危及器官剂量在正常范围内,治疗时间与准直器宽度成反比增加,但对螺距影响较小。本研究表明,采用5 cm准直器宽度生成的计划对肺癌脑转移患者是一种有效的方法。

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