De Long Nicole E, Barra Nicole G, Hardy Daniel B, Holloway Alison C
McMaster University, Department of Obstetrics and Gynecology , RM HSC-3N52, 1280 Main Street West, Hamilton, Ontario, L8S 4K1 , Canada +1 905 525 9140 ext. 22130 ; +1 905 524 2911 ;
Expert Opin Drug Saf. 2014 Dec;13(12):1721-31. doi: 10.1517/14740338.2014.973846. Epub 2014 Oct 21.
Worldwide, 10 to 35% of pregnant women smoke. It is clear that smoking cessation has positive impacts for both the mother and child, yet many women are still unable to quit due to the addictive properties of nicotine. There are limited data surrounding their safety and efficacy in pregnancy.
This review highlights evidence from clinical studies and animal experiments regarding the effects of smoking cessation therapeutics on pregnancy, neonatal and long-term postnatal outcomes.
There are insufficient data at this time to recommend the use of varenicline and/or bupropion for smoking cessation during pregnancy. In addition, the efficacy and safety of nicotine replacement therapy use for smoking cessation in pregnant women has not been clearly demonstrated. Until further studies are completed, there will continue to be considerable uncertainty regarding the use of these drugs in pregnancy despite the well-documented benefits of smoking cessation.
在全球范围内，10%至35%的孕妇吸烟。显然，戒烟对母亲和孩子都有积极影响，但由于尼古丁的成瘾性，许多女性仍然无法戒烟。关于它们在孕期的安全性和有效性的数据有限。
本综述强调了临床研究和动物实验中关于戒烟疗法对妊娠、新生儿及产后长期结局影响的证据。
目前尚无足够数据推荐在孕期使用伐尼克兰和/或安非他酮来戒烟。此外，尼古丁替代疗法用于孕妇戒烟的有效性和安全性尚未得到明确证实。在进一步研究完成之前，尽管戒烟有充分记录的益处，但这些药物在孕期的使用仍将存在相当大的不确定性。
