受损胆碱能神经元的存活、生长及功能

Survival, growth and function of damaged cholinergic neurons.

作者信息

Gage F H, Tuszynski M H, Chen K S, Armstrong D, Buzsáki G

机构信息

Department of Neurosciences, University of California at San Diego, La Jolla 92093.

出版信息

EXS. 1989;57:259-74. doi: 10.1007/978-3-0348-9138-7_26.

DOI:10.1007/978-3-0348-9138-7_26

PMID:2533097

Abstract

Recent progress has been made in defining the requirements for survival, growth and function of damaged cholinergic neurons of the central nervous system. In particular, the responsiveness of cholinergic neurons to nerve growth factor (NGF) in the regulation of development, cell survival, axon elongation, and response to injury has led to the formulation of the Neurotrophic Hypothesis, a unifying hypothesis of neuronal responsiveness to growth-promoting substances. NGF-mediated effects on cholinergic neurons in culture as well as in the septum, basal nucleus, striatum, and hippocampus, and the ability of NGF to prevent lesion-induced cell death and to ameliorate the effects of aging, provide the foundation for this work. A potential role for glia and microglia in mediating the effects of NGF is proposed.

摘要

在确定中枢神经系统受损胆碱能神经元的存活、生长和功能需求方面已取得了最新进展。特别是，胆碱能神经元在发育、细胞存活、轴突伸长及损伤反应的调节中对神经生长因子（NGF）的反应性，促使了神经营养假说的形成，这是一个关于神经元对生长促进物质反应性的统一假说。NGF对培养中的以及隔区、基底核、纹状体和海马体中的胆碱能神经元的介导作用，以及NGF预防损伤诱导的细胞死亡和改善衰老影响的能力，为这项工作奠定了基础。本文提出了神经胶质细胞和小胶质细胞在介导NGF作用方面的潜在作用。