用氟 - 18标记的麦芽六糖对细菌感染进行正电子发射断层扫描（PET）成像。
PET imaging of bacterial infections with fluorine-18-labeled maltohexaose.
作者信息
Ning Xinghai, Seo Wonewoo, Lee Seungjun, Takemiya Kiyoko, Rafi Mohammad, Feng Xuli, Weiss Daiana, Wang Xiaojian, Williams Larry, Camp Vernon M, Eugene Malveaux, Taylor W Robert, Goodman Mark, Murthy Niren
机构信息
Department of Bioengineering, UC Berkeley, 284 Hearst Memorial Mining Building, UC Berkeley, Berkeley, CA 94720 (USA).
Department of Radiology and Imaging Sciences, Emory University (USA).
出版信息
Angew Chem Int Ed Engl. 2014 Dec 15;53(51):14096-14101. doi: 10.1002/anie.201408533. Epub 2014 Oct 21.
Abstract
A positron emission tomography (PET) tracer composed of (18)F-labeled maltohexaose (MH(18)F) can image bacteria in vivo with a sensitivity and specificity that are orders of magnitude higher than those of fluorodeoxyglucose ((18)FDG). MH(18)F can detect early-stage infections composed of as few as 10(5) E. coli colony-forming units (CFUs), and can identify drug resistance in bacteria in vivo. MH(18)F has the potential to improve the diagnosis of bacterial infections given its unique combination of high specificity and sensitivity for bacteria.
摘要
一种由¹⁸F标记的麦芽六糖（MH¹⁸F）组成的正电子发射断层扫描（PET）示踪剂能够在体内对细菌进行成像，其灵敏度和特异性比氟脱氧葡萄糖（¹⁸FDG）高几个数量级。MH¹⁸F能够检测出仅由10⁵个大肠杆菌菌落形成单位（CFU）组成的早期感染，并能在体内识别细菌的耐药性。鉴于MH¹⁸F对细菌具有高特异性和高灵敏度的独特组合，它有潜力改善细菌感染的诊断。
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2
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J Nucl Med. 2014 Aug;55(8):1267-72. doi: 10.2967/jnumed.114.137232. Epub 2014 Jul 3.
3
Inflammation and infections in asthma.哮喘中的炎症与感染
Clin Respir J. 2015 Jul;9(3):257-69. doi: 10.1111/crj.12135. Epub 2014 May 15.
4
¹⁸F-FDG PET and PET/CT patient preparation: a review of the literature.¹⁸F-FDG 正电子发射断层显像及正电子发射断层显像/计算机断层扫描患者准备：文献综述
J Nucl Med Technol. 2014 Mar;42(1):5-13. doi: 10.2967/jnmt.113.132621. Epub 2014 Feb 6.
5
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Nat Chem. 2013 Nov;5(11):941-4. doi: 10.1038/nchem.1756. Epub 2013 Sep 8.
6
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7
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