Sfanos Karen S, Isaacs William B, De Marzo Angelo M
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD.
Am J Clin Exp Urol. 2013 Dec 25;1(1):3-11.
The frequent observation of both acute and chronic inflammation of unknown stimulus in the adult prostate has motivated a large body of research aimed at identifying potential infectious agents that may elicit prostatic inflammation. The overarching hypothesis is that infection-induced inflammation may be associated with prostate cancer development or progression, as inflammation is known to serve as an "enabling characteristic" of cancer. With recent advances in molecular techniques for microorganism identification, a panoply of microorganisms has been scrutinized in prostate tissues and in relation to prostate carcinogenesis. The aim of this review is to summarize the current literature on the evidence for infectious agents as a contributing factor to prostatic inflammation and prostate cancer, and to highlight recent literature suggesting an infectious etiology to the biogenesis of prostatic corpora amylacea and on the development of mouse models of prostatic infections.
在成年男性前列腺中频繁观察到不明刺激引发的急性和慢性炎症，这推动了大量研究，旨在确定可能引发前列腺炎症的潜在感染因子。总的假设是，感染诱导的炎症可能与前列腺癌的发生或进展相关，因为已知炎症是癌症的一种“促成特征”。随着微生物鉴定分子技术的最新进展，众多微生物已在前列腺组织中以及与前列腺癌发生相关的研究中受到仔细审查。本综述的目的是总结当前关于感染因子作为前列腺炎症和前列腺癌促成因素的证据的文献，并突出近期表明前列腺淀粉样体生物发生存在感染病因以及前列腺感染小鼠模型发展的文献。
