Dowsett M, Cantwell B M, Harris A L
Department of Biochemical Endocrinology, Royal Marsden Hospital, London, UK.
Horm Res. 1989;32 Suppl 1:209-12. doi: 10.1159/000181348.
In the postmenopausal woman, low plasma oestrogen levels are due to the cessation of ovarian follicular activity, and residual oestrogen is thought to result from the adrenal glands and ovaries, both sources of androgens for peripheral oestrogen synthesis. In a study of 21 postmenopausal women with advanced breast cancer, Zoladex (goserelin), 3.6 mg depot, monthly, had no affect on the adrenal-derived androgens, but a direct effect on ovarian secretion of androgens is thought to have occurred. Thus, in such women, medical adrenalectomy is likely to produce an incomplete suppression of plasma androgens, but its combination with Zoladex may provide a new therapeutic option.
在绝经后女性中，血浆雌激素水平低是由于卵巢卵泡活动停止，而残余雌激素被认为来自肾上腺和卵巢，这两者都是外周雌激素合成的雄激素来源。在一项针对21名晚期乳腺癌绝经后女性的研究中，每月一次注射3.6毫克长效醋酸戈舍瑞林（Zoladex）对肾上腺源性雄激素没有影响，但据认为对卵巢雄激素分泌有直接作用。因此，在此类女性中，药物性肾上腺切除术可能无法完全抑制血浆雄激素，但将其与Zoladex联合使用可能会提供一种新的治疗选择。
