Buslau M, Hänel H, Holzmann H
Zentrum der Dermatologie und Venerologie der Johann Wolfgang Goethe-Universität Frankfurt am Main.
Hautarzt. 1989 Oct;40(10):611-3.
The high prevalence of seborrheic dermatitis in HIV-infected subjects has led to intensified the discussion of the etiopathogenesis of this dermatological disease. There is increasing controversy about the significance of Pityrosporum in seborrheic dermatitis. On the other hand, recent clinical and experimental data favor the role of intestinal candidiasis in seborrheic dermatitis: a high quantity of Candida in the feces of the affected patients, elevated phospholipase activity of the Candida sp. with special pathogenic relevance for mucosal adhesion and fast and long-lasting regression of seborrheic dermatitis after vigorous therapy with oral nystatin. Similar findings have been recorded in the seborrheic forms of psoriasis.
脂溢性皮炎在HIV感染患者中的高发病率引发了对这种皮肤病病因发病机制的深入讨论。关于马拉色菌在脂溢性皮炎中的意义,争议越来越大。另一方面,最近的临床和实验数据支持肠道念珠菌病在脂溢性皮炎中的作用:患病患者粪便中存在大量念珠菌,念珠菌属的磷脂酶活性升高,这与黏膜黏附具有特殊的致病相关性,并且在口服制霉菌素进行积极治疗后,脂溢性皮炎能迅速且持久地消退。在银屑病的脂溢性形式中也记录到了类似的发现。