Qin Tingli, Jiang Hong, Jiao Yuan, Ke Yuannan, Sun Ningling, Wang Jiguang, Zhu Junren
Department of Cardiology, China-Japan Friendship Hospital, Beijing, China.
Department of Cardiology, China-Japan Friendship Hospital, Beijing, China
J Int Med Res. 2014 Dec;42(6):1323-34. doi: 10.1177/0300060514548288. Epub 2014 Oct 20.
To evaluate the relationship between ambulatory arterial stiffness index (AASI) and other parameters derived from ambulatory blood pressure (BP) monitoring, including dipping status, in patients with grade 1/grade 2 hypertension.
This retrospective analysis included baseline data from Chinese outpatients enrolled into a previous study, who had clinic diastolic BP of 90-109 mmHg and systolic BP <180 mmHg, had undergone 24-h ambulatory BP monitoring and routine blood chemistry investigations, and had estimated glomerular filtration rate (eGFR) data.
Out of 120 patients screened, 87 were included. No significant difference in 24-h AASI was found between dippers and nondippers. The 24-h AASI significantly correlated with age, systolic BP and pulse pressure, and inversely correlated with 24-h diastolic BP variation and eGFR. In dippers and nondippers, AASI correlated with daytime pulse pressure, daytime diastolic BP variation and eGFR; in nondippers, AASI also correlated with 24-h systolic BP and 24-h pulse pressure. The 24-h AASI was significantly associated with 24-h pulse pressure and daytime pulse pressure.
In patients with grade 1/grade 2 essential hypertension, AASI shows a significant correlation with ambulatory pulse pressure.
评估1级/2级高血压患者的动态动脉僵硬度指数（AASI）与动态血压（BP）监测得出的其他参数（包括血压波动状态）之间的关系。
这项回顾性分析纳入了之前一项研究中中国门诊患者的基线数据，这些患者的诊室舒张压为90 - 109 mmHg，收缩压<180 mmHg，接受了24小时动态血压监测和常规血液生化检查，且有估算肾小球滤过率（eGFR）数据。
在筛选出的120例患者中，87例被纳入研究。血压波动正常者和血压波动异常者的24小时AASI无显著差异。24小时AASI与年龄、收缩压和脉压显著相关，与24小时舒张压变异性和eGFR呈负相关。在血压波动正常者和血压波动异常者中，AASI与日间脉压、日间舒张压变异性和eGFR相关；在血压波动异常者中，AASI还与24小时收缩压和24小时脉压相关。24小时AASI与24小时脉压和日间脉压显著相关。
在1级/2级原发性高血压患者中，AASI与动态脉压显著相关。
