费城染色体阳性前体T细胞急性淋巴细胞白血病：一例罕见病例报告及简要综述
Philadelphia chromosome positive pre-T cell acute lymphoblastic leukemia: a rare case report and short review.
作者信息
Verrma Shailendra Prasad, Dutta Tarun Kumar, Vinod K V, Dubashi Biswajit, Ariga Kishore Kumar
机构信息
Division of Clinical Haematology, Department of Medicine, JIPMER, Pondicherry, India.
Department of Medicine, JIPMER, Pondicherry, India.
出版信息
Indian J Hematol Blood Transfus. 2014 Sep;30(Suppl 1):177-9. doi: 10.1007/s12288-013-0314-8. Epub 2014 Jan 22.
Abstract
Pre-T cell acute lymphoblastic leukemia is a relatively rare leukemia. Twenty to 30 % of adult B cell leukemia cases are Philadelphia chromosome positive and it has a therapeutic and prognostic significance. Incidence and outcome of Ph+ T cell acute lymphoblastic leukemia (T cell ALL) is unknown. Only about 25 cases of de novo Ph+ T cell ALL and 44 cases of Ph+ T ALL in blastic phase of CML has been reported. Differentiation between Ph+ Pre-T ALL/LBL and T cell lymphoblastic crises of chronic myeloid leukemia may be difficult. We report a case of adult T cell ALL having Philadelphia chromosome as the cytogenetic abnormality. He was treated with acute lymphoblastic leukemia induction chemotherapy and Imatinib and achieved complete remission.
摘要
前体T细胞急性淋巴细胞白血病是一种相对罕见的白血病。20%至30%的成人B细胞白血病病例费城染色体呈阳性，且具有治疗和预后意义。Ph+ T细胞急性淋巴细胞白血病（T细胞ALL）的发病率和预后尚不清楚。仅报告了约25例原发性Ph+ T细胞ALL以及44例慢性粒细胞白血病急变期的Ph+ T ALL病例。区分Ph+前体T ALL/LBL与慢性粒细胞白血病的T细胞淋巴母细胞危象可能存在困难。我们报告一例成人T细胞ALL病例，其细胞遗传学异常为费城染色体。该患者接受了急性淋巴细胞白血病诱导化疗和伊马替尼治疗，并实现了完全缓解。
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