Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
J Int Med Res. 2024 Feb;52(2):3000605231156757. doi: 10.1177/03000605231156757.
Philadelphia chromosome-positive (Ph+) T-cell acute lymphoblastic leukemia (T-ALL) is a rare and aggressive type of acute leukemia. The Philadelphia chromosome is the hallmark of chronic myeloid leukemia (CML). The differentiation between Ph+ T-ALL and T-cell lymphoblastic crisis of CML may be problematic in some cases. Here, we report a rare case of de novo Ph+ T-ALL that presented a diagnostic challenge. The overall clinical, immunophenotypic, cytogenetic, and xenotransplantation results suggest a diagnosis of Ph+ T-ALL. The patient was treated with induction chemotherapy including imatinib followed by haploidentical stem cell transplantation and achieved complete remission.
费城染色体阳性（Ph+）T 细胞急性淋巴细胞白血病（T-ALL）是一种罕见且侵袭性的急性白血病。费城染色体是慢性髓细胞白血病（CML）的标志。在某些情况下，Ph+T-ALL 与 CML 的 T 细胞淋系母细胞危象之间的区分可能存在问题。在这里，我们报告了一例新发 Ph+T-ALL 的罕见病例，该病例具有诊断挑战性。整体临床、免疫表型、细胞遗传学和异种移植结果提示 Ph+T-ALL 的诊断。该患者接受了包含伊马替尼的诱导化疗，随后进行了单倍体造血干细胞移植，达到了完全缓解。
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