Li Xuewei, Ping Nana, Wang Yong, Xu Xiaoyu, Gao Lijuan, Zeng Zhao, Zhang Ling, Zhang Zhibo, Xie Yiyu, Ruan Changgeng, Wu Depei, Jin Zhengming, Chen Suning
Department of Hematology, First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, Suzhou, China.
Department of Thrombosis and Hemostasis, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China.
Front Oncol. 2021 Jan 20;10:584149. doi: 10.3389/fonc.2020.584149. eCollection 2020.
Philadelphia chromosome positive (Ph) in T-lineage acute lymphoproliferative tumors is a rare event in both children and adults. In particular, it has not been reported in T-cell lymphoblastic lymphoma(T-LBL) yet. Here, we describe a patient with Ph T-LBL for both cytogenetic abnormality and fusion transcript. Moreover, we review the published cases of Ph T-cell acute lymphoblastic leukemia (T-ALL) in the literature and summarize their clinical characteristics, management, and prognosis.
费城染色体阳性（Ph）在T系急性淋巴细胞增殖性肿瘤中，无论在儿童还是成人中都是罕见事件。特别是，T细胞淋巴母细胞淋巴瘤（T-LBL）中尚未有相关报道。在此，我们描述了一名患有Ph T-LBL的患者，其存在细胞遗传学异常和融合转录本。此外，我们回顾了文献中已发表的Ph T细胞急性淋巴细胞白血病（T-ALL）病例，并总结了它们的临床特征、治疗及预后情况。
