Kudo T, Kudo M, Matsuki A, Oyama T
Masui. 1989 Jul;38(7):901-7.
Effects of various intravenous anesthetics and analgesics on alpha-rat atrial natriuretic peptide (alpha-rANP) concentrations in the plasma were studied in unrestrained rats. Morphine (30 mg.kg-1), fentanyl (0.2mg.kg-1) and buprenorphine (1mg.kg-1) produced 10-, 10- and 3.3-fold significant increases in plasma alpha-rANP over control group at 20min after intraperitoneal injections of each drug, respectively. A marked increase in plasma alpha-rANP after morphine administration was still observed at 60min, but those after fentanyl and buprenorphine were reduced to 4.7-from 10.0-fold and 1.6-from 3.3-fold increase at 60min, respectively. Pentazocine (40mg.kg-1) significantly increased plasma alpha-rANP to 1.3 times higher than that of control group only at 60 min, while ketamine (40mg.kg-1) caused an insignificant increase in plasma alpha-rANP to 1.4 and 1.3 times at 40 and 60 min. Droperidol (10mg.kg-1) tended to decrease plasma alpha-rANP and a significant reduction was observed at 60 min. Propofol (40mg.kg-1) did not affect on plasma alpha-rANP. Pentobarbital (50mg.kg-1) produced an insignificant fall in plasma alpha-rANP. Plasma levels of ACTH, compB and aldosterone increased after injections of morphine and fentanyl. These results indicate that mu-type opiate receptor plays an important role in secreting alpha-rANP and activating pituitary-adrenal axis in the rats.
在未拘束的大鼠中研究了各种静脉麻醉药和镇痛药对血浆中α-大鼠心房利钠肽（α-rANP）浓度的影响。分别腹腔注射吗啡（30mg·kg⁻¹）、芬太尼（0.2mg·kg⁻¹）和丁丙诺啡（1mg·kg⁻¹）后20分钟，血浆α-rANP较对照组分别显著升高10倍、10倍和3.3倍。注射吗啡后60分钟仍观察到血浆α-rANP显著升高，但注射芬太尼和丁丙诺啡后60分钟分别降至4.7倍（从10.0倍降至）和1.6倍（从3.3倍降至）升高。喷他佐辛（40mg·kg⁻¹）仅在60分钟时使血浆α-rANP显著升高至对照组的1.3倍，而氯胺酮（40mg·kg⁻¹）在40分钟和60分钟时使血浆α-rANP无显著升高至1.4倍和1.3倍。氟哌利多（10mg·kg⁻¹）倾向于降低血浆α-rANP，在60分钟时观察到显著降低。丙泊酚（40mg·kg⁻¹）对血浆α-rANP无影响。戊巴比妥（50mg·kg⁻¹）使血浆α-rANP无显著下降。注射吗啡和芬太尼后，促肾上腺皮质激素、补体B和醛固酮的血浆水平升高。这些结果表明μ型阿片受体在大鼠α-rANP分泌和激活垂体-肾上腺轴中起重要作用。
