Miyata A, Kangawa K, Matsuo H
J Hypertens Suppl. 1986 Jun;4(2):S9-11.
By using the sensitive radio-immunoassay specific for rat atrial natriuretic peptide (rANP) combined with chromatographic separation, we have determined molecular forms of rANP in rat tissues and plasma. Gamma-rat atrial natriuretic peptide is a major component of rANP in rat atria and ventricles, while alpha-rANP is a predominant form in the plasma, brain and submaxillary gland. Although molecular patterns in the adrenal and thyroid glands were very similar to that in the brain, a major immunoreactive (ir) alpha-rANP peak was accompanied by two minor peaks due to gamma-rANP and another unidentified ir-rANP. This variety in molecular forms suggests that the processing system for rANP precursors differs from tissue to tissue.
通过使用针对大鼠心房利钠肽（rANP）的灵敏放射免疫分析法并结合色谱分离法，我们已经确定了大鼠组织和血浆中rANP的分子形式。γ-大鼠心房利钠肽是大鼠心房和心室中rANP的主要成分，而α-rANP是血浆、脑和颌下腺中的主要形式。尽管肾上腺和甲状腺中的分子模式与脑中的非常相似，但一个主要的免疫反应性（ir）α-rANP峰伴随着两个由于γ-rANP和另一种未鉴定的ir-rANP产生的小峰。这种分子形式的多样性表明rANP前体的加工系统因组织而异。
