Nitta K, Sanaka T, Kawaguchi H, Tsuchiya K, Sone M, Takuma T, Sugino N
Jpn J Exp Med. 1987 Feb;57(1):41-5.
Following nephron reduction by means of five--sixths nephrectomy (Nx), nephritis was induced in rats by injection of nephrotoxic serum (NTS). A continuous intravenous infusion of synthetic rat--atrial natriuretic peptide (r-ANP) at 2.5 micrograms/min for produced remarkable diuresis and natriuresis in these rats. Furthermore, inulin clearance, para-amino-hippuric acid clearance and filtration fraction increased in spite of the reduction of mean arterial pressure during the infusion of r-ANP. It was therefore evident that diuresis and natriuresis were mediated by a direct action of r-ANP in the kidney. We observed that r-ANP was a diuretic, natriuretic and hypotensive agent but at a higher dosage in Nx rats with NTN.
通过六分之五肾切除术（Nx）减少肾单位后，给大鼠注射肾毒性血清（NTS）诱导肾炎。以2.5微克/分钟的速度持续静脉输注合成大鼠心房利钠肽（r-ANP）可使这些大鼠产生显著的利尿和利钠作用。此外，尽管在输注r-ANP期间平均动脉压降低，但菊粉清除率、对氨基马尿酸清除率和滤过分数增加。因此，很明显利尿和利钠是由r-ANP在肾脏中的直接作用介导的。我们观察到r-ANP是一种利尿剂、利钠剂和降压剂，但在患有NTN的Nx大鼠中剂量更高。
